Photochromic Compositions and Light Transmissible Articles

ABSTRACT

The invention relates to a photochromic polymeric composition comprising a polymer matrix and a photochromic compound which is an adduct comprising a photochromic moiety and at least one pendant oligomer group to provide a rate of fade of the photochromic polymeric composition which is significantly changed when compared with the corresponding composition comprising the photochromic compound without said pendent oligomer. The invention also relates to a photochromic compound which is an adduct comprising a photochromic moiety and at least one pendent oligomer.

FIELD

The present invention relates to a class of functionalised photochromic dyes, to compositions containing the functionalised dyes, and to a method for forming polymeric compositions and light transmissible polymeric articles exhibiting photochromic response.

BACKGROUND

Photochromism is a property which has been used in the manufacture of light transmissible articles for many years. A compound is said to be photochromic if it changes colour when irradiated and reverts to its original colour when irradiation ceases. The use of photochromics in the manufacture of spectacle lenses is a particular benefit as it enables the efficiency with which radiation is filtered to be varied with the intensity of radiation. Photochromics also have potential for use in a range of other polymeric compositions in products or in applications such as windows, automotive windshields, automotive and aircraft transparencies, polymeric films coating compositions, optical switches and data storage devices. Photochromics could also be used in inks and to improve the security of documents and currency, for example by providing a security check under UV light or by indicating exposure to light during photocopying.

Despite the use of photochromic compounds in applications such as lenses there have been a number of problems which reduce the versatility and potential of this technology.

It is advantageous to control the rate at which photochromic polymeric compositions colour when exposed to radiation and fade on cessation of this exposure. In many situations, it is important to provide rapid colouring and fading kinetics, particularly for lenses and spectacles. In some polymers however, the rate of coloration and fade is slow so that a compromise needs to be made in the components and properties of the substrate to enhance the rate of coloration and fade. For example, many photochromics colour and fade more rapidly in soft materials and yet, for applications such as spectacles or structural panels, abrasion resistance and hardness are important. This trade off between rate of transformation and hardness produces a dilemma for manufacturers between toughness and photochromic efficiency. In polymeric lenses many photochromics exhibit a slower rate of fade than is desirable. It would be desirable to have photochromic dyes which fade rapidly regardless of the hardness of the matrix.

One approach taken by previous workers is to produce photochromics which are an integral part of the host matrix. This is achieved by functionalising the photochromic with an unsaturated group which is polymerised with the polymer matrix. The photochromic thus becomes covalently tethered to the host polymer matrix. However unless the matrix is relatively soft the rate of fade is adversely effected. Hu et al, Pure Appln. Chem., AA(6) pp 803-810 (1996) also reported that tethering of the photochromic leads to the decolouration rate remaining almost constant with increasing dye concentration. Further the fade observed is significantly slower when this photochromic is tethered at concentrations less than 15 wt %.

Another example of cases where control of fade is desirable is with the a mixture of photochromic compounds. It is sometimes necessary to use a mixture of photochromic compounds to achieve the desirable colour such as brown or grey. However, the different photochromic dyes used in combination to achieve these colours often differ slightly in the rate of fade so that the mixture undergoes an unattractive variation in colour during fade. In other cases it may be desirable to reduce the rate of fade so that colouration or fade is gradual and controlled. For example in optical switches it may be desirable for the photochromic article to undergo rapid switching under specific thermal or electromagnetic stimulus but otherwise not fade under the ambient conditions of temperature and light.

Another problem associated with photochromic compounds is their lifetime. Many photochromic compounds have a relatively short lifetime before they fatigue, due to chemical degradation, and either no longer undergo reversible colour change or become less efficient. This is a problem, for example, in more hostile chemical environments such as in high index lenses containing sulfur-containing polymers or paper.

SUMMARY

We have now found that the photochromic properties of photochromic dyes in a polymeric substrate can be controlled by using a photochromic compound in which the photochromic moiety is functionalised to contain one or more pendant oligomer groups. Without wishing to be bound by theory we believe that certain oligomer groups provide a nanoenvironment to produce a significant change in the rate of fade. The one or more pendant oligomer groups change the rate of fade of the photochromic moiety in the polymeric matrix.

In one aspect the invention provides a photochromic polymeric composition comprising a polymer matrix and a photochromic compound which is an adduct comprising a photochromic moiety and at least one pendant oligomer group to provide a rate of fade of the photochromic polymeric composition which is significantly changed when compared with the corresponding composition comprising the photochromic compound without said pendent oligomer.

The oligomer is preferably not reactive the host matrix so that it does not become covalently tethered to the matrix polymer.

In a further aspect the invention provides a photochromic compound which is an adduct comprising a photochromic moiety and at least one pendant oligomer.

In the preferred embodiment of the invention the oligomer significantly increases the rate of fade so that the fade half life and/or the time taken to reach ¾ reduction in absorbance is reduced by at least 50% compared with the corresponding composition in absence of the oligomer.

DETAILED DESCRIPTION

In a rigid polymeric material of high glass transition temperature (Tg) the photochromic action of many photochromic compounds is reduced significantly when compared with softer materials. Without wishing to the bound by theory, we believe that the reduction in photochromic performance in polymeric substrates may occur as a result of the restriction in the volume available for the dye to transform by ring opening and/or effects of polar interaction.

One possible explanation of the more rapid transition observed for many compounds of the invention is that the oligomer chain may coil about the photochromic group to provide nanoencapsulation facilitating more rapid conversion between ring-open and ring-closed forms. The oligomer chains may provide a low Tg nanoenvironment or otherwise favourably alter the local environment. Accordingly it is preferred that the oligomer attached to the photochromic compound of the invention has a relatively low Tg. For example the Tg is preferably less than 25° C. More preferably the compounds of the invention are liquids at room temperature.

The compatibility of the oligomer chain with the host matrix may also influence the rate of fade.

The rate of fade of a photochromic chromophore may be slowed by using a plurality of oligomer substituents including a first oligomer chain and a second oligomer chain each on opposite sides of the photochromic moiety (such as spiro-oxazine group). This trend is especially the case as the Tg of the oligomers increases or they become more compatible with the host matrix. For example, in the case of spiro indolene aryleneoxazine compounds, one oligomer may be attached to fused benzene ring of the indolene portion and one oligomer chain attached to the aryl portion fused with the oxazine. When the oligomer chains are each compatible with the host matrix they may restrict motion of the photochromic moiety by becoming included into the matrix and restricting opposite ends of the spiro-oxazine. Fade speed may also be slowed by a single oligomer of relatively high Tg.

The trend in compatibility of an oligomer with the polymer matrix in many cases is consistent with polarity. Thus, an oligomer of similar polarity to the first polymer matrix is regarded as compatible. For example polyalkylene glycol oligomer groups are compatible with polar polymeric hosts such as acrylate and polyalkylene and poly(arylalkylene) oligomers are compatible with non-polar resins such as polyolefins and styrenic polymers (eg polystyrene, SBR etc) respectively.

We have also found that the nanoenvironment provided by the presence of one or more oligomer chains significantly improves the photochromic life of compounds of the invention when compared with unsubstituted photochromic compounds.

The invention relates to photochromic compounds comprising a photochromic moiety and at least one pendant oligomer group. Said at least one oligomer may be selected from the group consisting of polyether oligomers, polyalkylene oligomers, polyfluoroalkylene oligomers, poly fluoroalkylether oligomers, polydi(C₁ to C₁₀ hydrocarbyl)silyloxy oligomers, polysilicic acid oligomers (silicates) or derivatives thereof, poly (ZSi(OH)₃) oligomers and derivatives thereof, poly (ZSiCl₃) oligomers and derivatives thereof, poly (ZSi(OMe)₃) oligomers and derivatives thereof, and mixtures thereof wherein Z is an organic group. Preferably Z is selected from the group consisting of hydrogen, alkyl, optionally substituted alkyl, haloalkyl, cycloalkyl, optionally substituted cycloalkyl, hydroxy, amino, optionally substituted amino, alkoxy, aryloxy, aryl, optionally substituted aryl, carboxylic acid and derivatives thereof. A particularly preferred subset of these later oligomers are colloquially known as Polyhedral Oligomeric Silsesquioxanes (POSS). Compounds that contain a photochromic moiety and a POSS oligomer can display crystalline state photochromism.

The combined number of monomer units in the oligomers is preferably at least 5 and more preferably at least 7 and still more preferably at least 10. The oligomer and any group linking the oligomer to the chromophore preferably together provide a longest chain length of at least 12 atoms in the backbone of the chain, more preferably at least 15 atoms and most preferably at least 17 atoms.

The modified photochromics of the invention generally are of formula I (PC)-(L(R)_(n))_(m)  I

-   -   wherein     -   PC is the photochromic moiety;     -   L is a bond or linking group;     -   R is an oligomer chain;     -   n is an integer of from 1 to 3;     -   m is an integer of from 1 to 3 and         wherein the total number of monomer units in the oligomer         groups (R) is at least 5, preferably at least 7, more preferably         at least 10. It is particularly preferred that the linking group         (when present) and the oligomer [ie. the radical .L(R)n)m]         together provide a longest chain length of at least 12 atoms,         more preferably at least 15 atoms and most preferably 17 to 40         atoms in the chain backbone.

Examples of suitable oligomer groups R include groups of formula 1a: —(X)_(p)(R¹)_(q)—R²  I(a) wherein: X is selected from oxygen, sulfur, amino such as C₁ and C₆ alkyl amino, C₁ to C₄ alkylene (preferably methylene); p is 0 or 1; q is the number of the monomer units R¹ in said oligomer and is preferably at least 5; R¹, which may be the same or different, are selected from the group consisting of: C₂ to C₄ alkylene such as ethylene, propylene and butylene; halo (C₂ to C₄ alkylene) such as perfluoroethylene, perfluoropropylene, and perfluorobutylene; C₂ to C₄ alkyleneoxy; C₂ to C₄ haloalkyleneoxy; di(C₁ to C₁₀ hydrocarbyl)silyloxy wherein the hydrocarbyl may be alkyl, aryl alkyl substituted aryl or aryl substituted alkyl and particularly di(C₁ to C₄ alkyl)silyloxy such as dimethylsilyloxy; and R² is selected from hydrogen, C₁ to C₆ alkyl and C₁ to C₆ haloalkyl, hydroxy, optionally substituted amino, optionally substituted aryl carboxylic acid and derivatives thereof and preferably R² is selected from the group consisting of hydrogen, C₁ to C₆ alkyl, substituted amino, optionally substituted aryl and alkyl and aryl esters of carboxyl.

Examples of suitable oligomer group R also include groups of formula 1B or 1C

wherein Z is an organic group, preferably an organic group selected from the group consisting of hydrogen, alkyl, optionally substituted alkyl, haloalkyl, cycloalkyl, optionally substituted cycloalkyl, hydroxy, amino, optionally substituted amino, alkoxy, aryloxy, aryl, optionally substituted aryl, carboxylic acid and derivatives thereof. It is particularly preferred that Z is selected from the group consisting of isobutyl, iso-ocytl, cyclopentenyl, cyclohexyl and phenyl.

The oligomer group preferably does not contain groups which undergo radical or condensation reactions. Thus the oligomer will generally not have a terminal unsaturated group or terminal activated hydrogen such as amino hydroxyl or carboxyl.

Preferably L is selected from the group consisting of a bond or the polyradical selected from the group of formula IIa, IIb, IIc, IId, IIe, IIf, IIg, IIl, IIi, IIj and IIk.

wherein n is from 1 to 3;

wherein in the formula IIa to IIk:

-   -   X which may be the same or different is as hereinbefore defined;     -   R⁴ is selected from the group consisting of hydroxy, alkoxy,         amino and substituted amino such as alkyl amino;     -   n is an integer from 1 to 3;     -   w is an integer from 1 to 4;     -   q is an integer from 0 to 15;     -   p which when there is more than one may be the same or different         is 0 or 1; and     -   (R) shows the radial for attachment of oligomer R.

The purpose of the linking group is to join the oligomer(s) to the photochromic moiety. A linking group may be needed when the oligomer has a functional group that cannot be used directly to join to the dye. For example the terminal hydroxyl of a PEG oligomer can be converted to an acid by reaction with succinic anhydride. This could then be readily joined to the hydroxy group on a photochromic moiety such as 9′-hydroxy-1,3,3-trimethylspiro[indoline-2,3′-93H]naphtha[2,1-b][1,4]oxazine]. Another example is in Example 16 where the carboxylic acid on the chromene was esterified with ethylene glycol to provide a hydroxy group that can react with the acid group (via the acid chloride) of the poly(dimethylsiloxane)monocarboxydecyl chloride.

The linking group may in some case be available as part of the oligomer. For example in the examples we demonstrate the use of poly(dimethylsiloxane) monocarboxydecyl chloride. The undecyl carboxy group is part of the commercially available oligomer MCR-B11 and acts as the linking group between the dye and the oligomer.

Specific examples of linker groups L include:

The compounds of the present invention comprise oligomer groups wherein the total number of monomeric units is as least 5, preferably at least 7, and most preferably at least 10. The oligomer chain and linking group preferably provide a longest chain length of at least 12 atoms, more preferably at least 15 atoms and most preferably from 17 to 40 atoms. The chain length we refer to here is the number of atoms linked in sequence in the polymer backbone.

The oligomer(s) may be in the form of linear chains, branched chains, copolymers including block or random copolymers; however, it is particularly preferred that each oligomer comprise at east 5 monomer units of the same type, and more preferably at least 7.

Preferably, the monomer units are selected from the groups consisting of perfluruoalkylene, alkylene, arylalkylene, alkyleneoxy, haloalkyleneoxy, and di(C₁ to C₁₀ hydrocarbyl)silyloxy. More preferred monomer units are alkyleneoxy, and dialkylsilyloxy and even more preferred are ethyleneoxy, propyleneoxy and random and block copolymers thereof.

The photochromic compound of the invention of formula I includes up to three groups each of which may include one, two or three oligomer groups R.

Examples of preferred oligomer groups include

wherein the monomer units are distributed randomly or in block form

wherein Ø is alkyl or aryl and includes at least a portion of aryl groups Xp(CF₂CF₂O)x-(CF₂)nCF₃  (vii) wherein X and R² and p are hereinbefore defined and x, v and y are the number of repeating units, and alkyl is C₁ to C₂₀ alkyl, preferably C₁ to C₁₀ alkyl such as methyl, ethyl, propyl, butyl, pentyl or hexyl. Preferably the compounds of the invention include at least one oligomer group wherein the number of monomer units (x or y+v in the above examples) is at least 7 and are most preferably at least 10.

A further preferred oligomer group is a group of formula:

wherein Z is an organic group, preferably an organic group selected from the group consisting of hydrogen, alkyl, optionally substituted alkyl, haloalkyl, cycloalkyl, optionally substituted cycloalkyl, hydroxy, amino, optionally substituted amino, alkoxy, aryloxy, aryl, optionally substituted aryl, carboxylic acid and derivatives thereof. It is particularly preferred that Z is selected from the group consisting of isobutyl, iso-ocytl, cyclopentenyl, cyclohexyl and phenyl.

The most preferred oligomer groups contain at least 10 monomer units. The monomer units may be up to thirty or more units in length but we have found the range of from 10 to 30 to be particularly suitable.

It will be appreciated by those skilled in the art that the presence and nature of the group X is dependent on the linker group. When the linker group is a bond and the oligomer is linked to a heteroatom such as nitrogen, then p is preferably zero.

However, when the group L-(R)_(n) is attached to a carbon radical of the photochromic moiety, or a linker of formula IIa to IIk then in the oligomer group R the integer, p is preferably 1.

The photochromic moiety may be chosen from a wide range of photochromic moieties known in the art. The most appropriate photochromic moieties for use in the compounds used in accordance with the invention are photochromics which undergo a molecular isomerism such as a cis-trans isomerism or pericyclic reaction such as 6π, −6 atom, 6π, −5 atom processes and [2+2], [4+4] or [4+2]cycloadditions. The compositions of the invention (and in particular the oligomer chains) are believed to provide a nanoenvironment to provide a desired environment which may lead to a more rapid transformation between the colour-producing chromophore and colourless state of the photochromics.

Photochromic oligomer adducts in accordance with the invention may comprise a photochromic moiety selected from the group consisting of:

-   -   chromenes such as those selected from the group consisting of         naphthopyrans, benzopyrans, indenonaphthopyrans and         phenanthropyrans;     -   spiropyrans such as those selected from the group consisting of         spiro(benzindoline) naphthopyrans, spiro(indoline)benzopyrans,         spiro(indoline)-naphthopyrans, spiroquinopyrans, and         spiro(indoline)pyrans and spirodihydroindolizines;     -   spiro-oxazines such as those selected from the group consisting         of spiro(indoline)naphthoxazines,         spiro(indoline)pyridobenzoxazines,         spiro(benzindoline)pyridobenzoxazines,         spiro(benzindoline)naphthoxazines and         spiro(indoline)-benzoxazines;     -   fulgidies, fulgimides;     -   anils;     -   perimidinespirocyclohexadienones;     -   stilbenes;     -   thioindigoids;     -   azo dyes; and     -   diarylethenes.

Examples of photochromic moieties may be selected from the group consisting of fulgide photochromic compounds, chromene photochromic compounds and spiro-oxazine photochromic compounds. A wide range of photochromic compounds of each of the classes referred to above have been described in the prior art and having regard to the teaching herein the skilled addressee will have no difficulty in preparing a wide range of photochromic oligomer adducts. Examples of chromene photochromic compounds, fulgide photochromic compounds and spiro-oxazine photochromic compounds are described in U.S. Pat. No. 5,776,376.

The most preferred photochromic compounds are the chromenes and spiro-oxazines, specifically spiroindolene aroxazines.

Sprio-oxazines such as sprioindoline naphthoxazines depicted below are clear but in the presence of light undergo ring opening to give a coloured form as shown:

A further embodiment of the invention is a photochromic compound of formula (PC)—(X)_(p)L(R)_(n) wherein PC is a photochromic moiety particularly a spirooxazine of formula III, chromene of formula XX, fulgide/fulgamide of formula XXX or an azo dye of formula XL and L, R, X and n and p are as hereinbefore defined. Formulae III, XX, XXX and XL are described below with reference to examples.

Preferred spiro-oxazines of the general formula III can be suitably used.

In the general formula III, R³, R⁴ and R⁵ may be the same or different and are each an alkyl group, a cycloalkyl group, a cycloarylalkyl group, an alkoxy group, an alklyleneoxyalkyl group, an alkoxycarbonyl group, a cyano, an alkoxycarbonylalkyl group, an aryl group, an arylalkyl group, an aryloxy group, an alkylenethioalkyl group, an acyl group, an acyloxy group or an amino group, R⁴ and R⁵ may together form a ring, and R³, R⁴ and R⁵ may optionally each have a substituent(s). The substituent(s) can includes (include), besides the above-mentioned groups, halogen atom, nitro group, heterocyclic group, etc. The group represented by moiety IIIa

is a substituted or unsubstituted bivalent aromatic hydrocarbon group or a substituted or unsubstituted bivalent unsaturated heterocyclic group. The group represented by moiety IIIb

is a substituted or unsubstituted bivalent aromatic hydrocarbon group or a substituted or unsubstituted bivalent unsaturated heterocyclic group. Specific examples of the bivalent aromatic hydrocarbon group are groups of 6 to 14 carbon atoms derived from benzene ring, naphthalene ring, phenanthrene ring, anthracene ring or the like. Specific examples of the bivalent unsaturated heterocyclic group are groups of 4 to 9 carbon atoms derived from furan ring, benzofuran ring, pyridine ring, quinoline ring, isoquinoline ring, pyrrole ring, thiophene ring, thiophene ring, benzothiophene ring or the like.

The substituents can be the same groups as mentioned above with respect to R³, R⁴ and R⁵. In particular, a group represented by —NR⁶R⁷ (wherein R⁶ and R⁷ are each an alkyl group, an alkoxy group, an allyl group or the like, each of which may be substituted; and R⁶ and R⁷ may be bonded and cyclized with each other to form a nitrogen-containing heterocyclic ring) is preferable from the standpoint of high density of its developed colour in the initial photochromic performance.

In a particularly preferred embodiment the photochromic compounds of the invention are of formula IV

wherein R³, R⁴, R⁵, R⁸ R⁹, R¹⁰ and R¹¹ are independently selected from the group consisting of hydrogen, alkyl, halo, haloalkyl, cycloalkyl, cycloarylalkyl, hydroxy, alkoxy, alkyleneoxyalkyl, alkoxycarbonyl, aryl, arylalkyl, aryloxy, alkylenethioalkyl, acyl, acyloxy, amino, NR⁶R⁷, cyano and the group L(R)_(n) wherein at least one of R³, R⁸ and R⁹ is the oligomer group of formula L(R)_(n) wherein L, R and n are hereinbefore defined and wherein there is more than one L(R)_(n) group in the groups R⁸, R³, R⁴ and R⁵ and one or more R groups may optionally be linked together to form one or more bridging oligomers. The subscript m is an integer and may be 0, 1 or 2 wherein m is 2 the groups may be independently selected.

In the compound of formula IV the total of the number of monomer units in oligomer substituents, (R)_(n), is at least 7 and preferably at least 12.

More preferably, the substituents R³ is selected from the group consisting of alkyl, cycloalkyl, cycloarylalkyl, alkyleneoxyalkyl, aryl, arylalkyl alkylenethioalkyl, and the group L(R)_(n) and more preferably R³ is selected from alkyl, cycloalkyl, cycloarylalkyl, alkenyloxyalkyl, aryl, arylalkyl, and the group L(R)_(n) and preferably R⁴ and R⁵ are indefinitely selected from alkyl, cycloalkyl and aryl.

R⁸ and R⁹ are independently selected from hydrogen and L(R)_(n); R¹⁰ and R¹¹ are independently selected from the group consisting alkyl, cycloalkyl, cycloarylalkyl, alkoxy, —NR⁶R⁷, cyano, alkyleneoxyalkyl, alkoxycarbonyl, aryl, arylalkyl, aryloxy, alkylenethioalkyl, aryl aryloxy and amino and most preferably R¹⁰ and R¹¹ are independently selected from alkyl, cycloalkyl, alkoxy, NR⁶R⁷ and cyano; and

m is or 1.

Examples of the preferred fused aromatic ring groups of formula IIIa include IIIa(i);

wherein R⁹ and R¹¹ are as hereinbefore defined.

Examples of the preferred fused aromatic ring group of formula IIIb include IIIb(i), IIIb(ii), IIIb(iii) and IIIb(iv).

Specific examples of the group of formula IIIa(i) include

Specific examples of the group of formula IIIb include

One particularly preferred embodiment of the compounds of formula IV has the formula IVa

The more preferred compounds of formula IVa are compounds wherein R⁴ and R⁵ are preferably independently selected from the group consisting of C₁ to C₄ alkyl and the group wherein R⁴ and R⁵ link together to form a cycloalkyl of from 4 to 6 carbon atoms.

R⁸ and R⁹ are independently selected from the group consisting of hydrogen, halogen, cycloalkyl, cycloarylalkyl, hydroxy alkoxy, cyano, alkenyloxyalkyl, alkoxycarbenzyl, aryl, aralkyl, aryloxy, alkylene, thioalkyl and the oligomer of formula L(R)_(n) wherein L, R and n are as hereinbefore defined;

R¹⁰ and R¹¹ are independently selected from the group consisting of hydrogen, halogen, cycloalkyl, cycloarylalkyl, alkoxy, cyano, alkenyloxyalkyl, alkoxycarbonyl, aryl, arylalkyl, acyloxy and alkylenethioalkyl. Most preferably R¹⁰ and R¹¹ are hydrogen; and at least one of R⁸ and R⁹ is the group L(R)_(n) wherein the total number of monomer units in R is at least 10 and more preferably at least 12.

In order to provide an increase in fade rate of the photochromic in a polymer (preferably a polymer of high Tg) article, the size of the polymer chain must be greater than a certain size. The minimum size will depend on the nature of the oligomer chain and the linking group. It is believed that the fade is significantly accelerated where a polymer chain may adopt a conformation in which a portion of the chain is adjacent the oxazine ring. Accordingly, linking groups which direct the oligomer chain across the molecule (such as the group of formula VI to VIII comprising at least one polymer chain R in a portion otho to the link) may enable the minimum number of effective monomer units to be reduced when compared with other linking groups.

Surprisingly, we have found that a single substituent containing at least one oligomer chain may accelerate fade in a wide variety of polymers whereas in the case of at least two oligomer chains, each on opposite sides of the oxazine ring, the rate of fade of photochromic compounds in polymers may be reduced. Without wishing to be bound by theory, we believe that interaction between oligomer chains on opposite sides of the oxazine portion with the host polymer may restrict or constrain the photochromic molecule to reduce the rate of ring opening and closure of the spiro-oxazine.

Accordingly, in one preferred embodiment one of R³, R⁸ and R⁹ is L(R)_(n) where the R groups together include at least 10 monomer units. Alternatively, R⁸ and at least one of R⁹ and R³ (preferably R⁹) is L(R)_(n) and the two or more groups L(R)_(n) contain at least 10 monomer units.

Specific examples of compounds of the invention include those listed in Table 1. TABLE 1

R⁸ R³ R⁹ R¹⁰ R¹¹ 1 9′-O(CO)(CH₂)₂CO₂(EO)₇CH₃ CH₃ H H H 2 9′-O(CO)(CH₂)₂CO₂(EO)₁₆CH₃ CH₃ H H H 3 9′-O(CO)(CH₂)₂CO₂(EO)₇CH₃ CH₃ 5-O(CO)(CH₂)₂CO₂(EO)₇CH₃ H H 4 H (EO)₇CH₃ H H H 5 9′-O(CO)(CH₂)₂CO₂(EO)₁₀CH₃ CH₃ H H H 6 9′-OCO(CH₂)₂CO₂(EO)₂₀CH₃ CH₃ H H H 7 6′-OCO(CH₂)₂CO₂(EO)₁₆CH₃ CH₃ H H H 8 6′-N(CH₂CH₃)CH₂CH₂O(EO)₁₆CH₃ CH₃ H H H 9 9′-OCO(CH₂)₂CO₂(EO)₁₆CH₃ CH₃ H 6′- H N(Et)₂ 10 H CH₃ 5-O(CO)(CH₂)CO₂(EO)₁₆CH₃ H H 11

CH₃ H H H 12

CH₃ H H H 13 H CH₃ 5-O(CO)(CH₂)₂CO₂(EO)₁₆CH₃ H H 14 H CH₃ 5-O(CO)(CH₂)₂CO₂(EO)₁₀CH₃ H H 15 H CH₃ 5-O(CO)(CH₂)₂CO₂(EO)₂₀CH₂ H H 16 H CH₃ 5-NH(CH₂CH₃)CH₂CH₂O(EO)₁₆CH₃ H H 17 H CH₃

H H 18 H CH₃

H H 19 H CH₃ 5-O(CO)(CH₂)₂CO₂(EO)₇CH₃

H 20 H CH₃ 5-O(CO)(CH₂)₂CO₂(EO)₁₆CH₃

H 21 H CH₃

H 22 H CH₃

H 23 H CH₃ 5-O(CO(CH₂)₂CO₂(EO)₇CH₃ 6-CN H 24 H CH₃ 5-O(CO(CH₂)₂CO₂(EO)₁₆CH₃ 6-CN H 25 H CH₃

6-CN H 26 H CH₃

6-CN H 27 H CH₃ 5-CH₂NH(CO)CH₂)₂CO₂(EO)₁₆CH₃ 6-CN H 28 H CH₃ 5-CH₂NH(CO)CH₂)₂CO₂(EO)₁₆CH₃

H 29 H CH₃ 5-CH₂NH(CO)CH₂)₂CO₂(EO)₁₆CH₃ 6-H H 30 9′-O—(CO)(CH2)10-PDMS(855) CH₃ H H H 31 9′-O—(CO)(CH2)10-PDMS(855) CH₂—CH(CH₃)₂ 32 9′-O—(CO)(CH2)10-PDMS(855) CH₃—C(CH₃)₃ H H H 33 9′-O—(CO)(CH2)10-PDMS(855) CH₃ H 6′- H N(Et)2 34 9′-O—CH₂CH₂—O—(CO)(CH2)10- CH₃ H H H PDMS(855) 35 9′-O—CH₂CH₂—O—(CO)(CH2)10- CH₃ H 6′- H PDMS(855) N(Et)2 36 9′-O—(CO)(CH2)10-PDMS(855) CH₃ 5-OCH₃ H H 37 9′-O—(CO)(CH2)10-PDMS(855) CH₃ 5-OCH₃ 6′- H N(Et)2 38 9′-O—CH₂CH₂—O—(CO)(CH2)10- CH₃ 5-OCH₃ H H PDMS(855) 39 9′-O—CH₂CH₂—O—(CO)(CH2)10- CH₃ 5-OCH₃ 6′- H PDMS(855) N(Et)2 40 H CH₃ 5-O—(CO)(CH₂)10-PDMS(855) H H 41 H CH₃—CH(CH₃)₂ 5-O—(CO)(CH₂)10-PDMS(855) H H 42 H CH₂—C(CH₃)₃ 5-O—(CO)(CH₂)10-PDMS(855) H H 43 H CH₃ 5-O—(CO)(CH₂)10-PDMS(855) 6′-CN H 44 H CH₃ 5-O—(CO)(CH₂)10-PDMS(855) 6′- H N(Et)2 45 H CH₂—C(CH₃)₃ 5-O—(CO)(CH₂)10-PDMS(855) 6′- H N(Et)2 46 H CH₃ 5-O—CH₂CH₂—O—(CO)(CH2)10- H H PDMS(855) 47 H CH₃ 5-O—CH₂CH₂—O—(CO)(CH2)10- 6′- H PDMS(855) N(Et)2 48 H CH₃ 5-O—CH₂CH₂—O—(CO)(CH2)10- 6′-CN H PDMS(855) 49 H CH₂—C(CH₃)₃ 5-O—CH₂CH₂—O—(CO)(CH2)10- 6′- H PDMS(855) N(Et)2 50 O—CO—CH₂CH₂—COO—CH₂CH₂CH₂- CH₃ H H H ((hepta-isobutyl)POSS) wherein (EO) is the group (CH₂CH₂O). and PDMS (855)=polydimethylsiloxane with an average molecular weight of 855 including a terminal butyl dimethyl silane end group.

Further preferred compounds are provided in Table 2 TABLE 2

R9 R3 R11 R12 R13 1 5-O—(CO)(CH₂)10-PDMS(855) CH₃ H Me Me 2 5-O—(CO)(CH₂)10-PDMS(855) CH₃ H Et Ft 3 5-O—(CO)(CH₂)10-PDMS(855) CH₃ H pyrrolidino 4 5-O—(CO)(CH₂)10-PDMS(855) CH_(2—CH(CH) ₃)₂ H Me Me 5 5-O—(CO)(CH₂)10-PDMS(855) CH₂—CH(CH₃)₂ H Et Et 6 5-O—(CO)(CH₂)10-PDMS(855) CH₂—CH(CH₃)₂ H pyrrolidino 7 5-O—(CO)(CH₂)10-PDMS(855) CH₂—C (CH₃)₃ H Me Me 8 5-O—(CO)(CH₂)10-PDMS(855) CH₂—C (CH₃)₃ H Et Et 9 5-O—(CO)(CH₂)10-PDMS(855) CH₂—C (CH₃)₃ H pyrrolidino 10 5-O—CH₂CH₂—O—(CO)(CH2)10- CH₃ H Me Me PDMS(855) 11 5-O—CH₂CH₂—O—(CO)(CH2)10- CH₃ H Et Et PDMS(855) 12 5-O—CH₂CH₂—O—(CO)(CH2)10- CH₃ H pyrrolidino PDMS(855) 13 5-O—CH₂CH₂—O—(CO)(CH2)10- CH₂—CH(CH₃)₂ H Me Me PDMS(855) 14 5-O—CH₂CH₂—O—(CO)(CH2)10- CH₂—CH(CH₃)₂ H Et Et PDMS(855) 15 5-O—CH₂CH₂—O—(CO)(CH2)10- CH₂—CH(CH₃)₂ H pyrrolidino PDMS(855) 16 5-O—CH₂CH₂—O—(CO)(CH2)10- CH₂—C (CH₃)₃ H Me Me PDMS(855) 17 5-O—CH₂CH₂—O—(CO)(CH2)10- CH₂—C (CH₃)₃ H Et Et PDMS(855) 18 5-O—CH₂CH₂—O—(CO)(CH2)10- CH₂—C (CH₃)₃ H pyrrolidino PDMS(855) 19 —O—CO—CH₂CH₂—COO—CH₂CH₂CH₂- CH₃ H Me Me ((hepta-isobutyl)POSS) 20 —O—CO—CH₂CH₂—COO—CH₂CH₂CH₂- CH₃ H Et Et ((hepta-isobutyl)POSS) 21 —O—CO—CH₂CH₂—COO—CH₂CH₂CH₂- CH₃ H pyrrolidino ((hepta-isobutyl)POSS) 22 —O—CO—CH₂CH₂—COO—CH₂CH₂CH₂- CH₂—CH(CH₃)₂ H Me Me ((hepta-isobutyl)POSS) 23 —O—CO—CH₂CH₂—COO—CH₂CH₂CH₂- CH₂—CH(CH₃)₂ H Et Et ((hepta-isobutyl)POSS) 24 —O—CO—CH₂CH₂—COO—CH₂CH₂CH₂- CH₂—CH(CH₃)₂ H pyrrolidino ((hepta-isobutyl)POSS) 25 —O—CO—CH₂CH₂—COO—CH₂CH₂CH₂- CH₂—C (CH₃)₃ H Me Me ((hepta-isobutyl)POSS) 26 —O—CO—CH₂CH₂—COO—CH₂CH₂CH₂- CH₂—C (CH₃)₃ H Et Et ((hepta-isobutyl)POSS) 27 —O—CO—CH₂CH₂—COO—CH₂CH₂CH₂- CH₂—C (CH₃)₃ H pyrrolidino ((hepta-isobutyl)POSS)

The more preferred compounds of the invention are of formula (Ivb)

where the substituents are hereinbefore described and even more preferably R³ is C₁ to C₄ alkyl; C₃ to C₆ cycloalkyl, aryl, alkylaryl, arylalkyl and L(R)_(n); R^(5a) and R^(5b) are independently selected from C₁ to C₆ alkyl C₃ to C₆ cycloalkyl, aryl; R⁸ and R⁹ are selected from hydrogen, hydroxy, C₁ to C₆ alkoxy; R¹⁰ is selected from the group hydrogen, hydroxy, C₁ to C₆ alkoxy —NR⁶R⁷ wherein R⁵ and R⁷ are independently hydrogen, C₁ to C₆ alkyl and wherein R⁶ and R⁷ may together form a divisional hydrocarbon chain of 4 to 6 carbon atoms.

As we have discussed above, in order to maximise the rate of colouration and fade in polar and non-polar polymers it is preferred that one of R³, R⁸ and R⁹ is L(R)_(n) comprising at least 10, more preferably at least 12 monomer units and the other two of R³, R⁸ and R⁹ are other than L(R)_(n) where L(R)_(n) contains 7 monomer units.

In compounds where more than one of R³, R⁸ and R⁹ is L(R)_(n) comprising at least 7 monomer units, the effect on the rate of colouration and fade will depend to some extent on the oligomer and type of polymer. In cases where the polymer and oligomers are compatible, the rate of fade may be decreased and when the oligomer and resin are less compatible, the effect may be less or fade may be increased.

We have found that for compounds of formula IV a (preferably IVb) if R⁸ and R⁹ are shorter chains or smaller substituents they are also useful in controlling the rate of fade though to a more limited extent.

In a further embodiment, the invention therefore provides compounds of formula IVa (preferably IVb) wherein R⁸ and R⁹ are each selected from groups of formula I and groups of formula L(R)_(n) as hereinbefore defined and the group LR¹¹ wherein R¹¹ is lower alkyl, lower haloalkyl, lower polyalkyleneoxy aryl and aryl(lower alkyl). The term lower is used to mean up to 6 carbon atoms in the chain and preferably up to 4.

In yet another embodiment we provide an intermediate for preparation of compounds of the invention, the intermediate being of formula IVa and more preferably IVb wherein R⁸ and R⁹ are selected from XH wherein X is hereinbefore defined. Preferably R⁸ and R⁹ are the same.

Compounds of the invention may be prepared by reaction of intermediates Va or Vb and VI.

One method for preparing compounds of the invention comprises reacting a methylene indolene of formula Va or Fishers base or indolium salt of formula Vb where J is halogen, particularly the iodide salt, wherein R¹³ is R⁹ and R¹⁴ is R³ with a nitrosohydroxy compound of formula VI to provide a compound of the invention of formula IV.

Alternatively, a methylene indolene of formula Va or indolium salt of formula Vb may be reacted with a nitrosohydroxy compound of formula VI wherein R¹² and R¹³ are independently selected from the group consisting of hydrogen and —XH and at least one of R¹² and R¹³ is —XH to provide an intermediate of formula VII.

and reacting the compound of formula VIII with a compound of formula VII JL(R)_(n)  VIII wherein J is a leaving group to form a compound of formula IV wherein at least one of R⁸ and R⁹ are the group L(R)_(n).

Alternatively or in addition the compound of formula IV wherein R³ is L(R)_(n) may be prepared by (a) reacting the compound of formula Va or Vb with a compound of formula VIII to provide a compound of formula Va and Vb where R¹⁴ is L(R)_(n) and reacting the compound of formula VIa or VIb with a compound of formula VI to provide a compound of formula IV wherein R³ is L(R)_(n).

Specific examples of compounds of formula VIII, include J L(R)_(n) where J is chlorine, L is of formula IIa to IIc where p is O and R is any one of the R group examples (i) to (v) shown above.

Compounds of formula IV where L is a bond may additionally be prepared by using a toluene sulfonyl leaving group for example by reaction of the compound of formula IX

with a compound of formula IV wherein at least one of R⁸ or R⁹ is XH and/or R³ is hydrogen to provide a compound where one or more groups is alkoxylated.

Compounds of formula X

having a wide variety of the fused aromatic groups B may be prepared using the intermediate of formula Vc.

The fused aromatic group B and its substituents may be chosen to provide the disused colour of the photochromic compound. Such compounds provide a versatile method of preparation of rapid fade spiroindolineoxazines.

Examples of suitable substituted methylene indolene compounds of formula Va and Vb include 5-amino indolene compounds described by Gale & Wiltshire (J. Soc. Dye and Colourants 1974, 90, 97-00), 5-amino methylene compounds described by Gale, Lin and Wilshire (Aust. J. Chem. 1977 30 689-94) and 5-hydroxy compounds described in Tetrahedron Lett. 1973 12 903-6 and in U.S. Pat. No. 4,062,865.

One of the preferred groups of photochromics are the spiropyrans. Examples of spiropyrans include compounds of formula XIX and XX

wherein in XIX the groups X, Y, Z and Q may be substituents including where one or more thereof form a carbocyclic ring optionally fused with aryl and the substituents R²³ and R²⁴ may be present in any ring; and wherein

-   -   B and B′ are optionally substituted aryl and heteroaryl; and     -   R²², R²³ and R²⁴ are independently selected from hydrogen;         halogen; C₁ to C₃ alkyl; the group L(R)_(n); and the group of         formula COW wherein W is OR²⁵, NR²⁶R²⁷, piperidino or morpholino         wherein R²⁵ is selected from the group consisting of C₁ to C₆         alkyl, phenyl, (C₁ to C₆ alkyl)phenyl, C₁ to C₆ alkoxyphenyl,         phenyl C₁ to C₆ alkyl (C₁ to C₆ alkoxy)phenyl, C₁ to C₆ alkoxy         C₂ to C₄ alkyl and the group L(R)_(n); R²⁶ and R²⁷ are each         selected from the group consisting of C₁ to C₆ alkyl, C₅ to C₇         cycloalkyl, phenyl, phenyl substituted with one or two groups         selected from C₁ to C₆ alkyl and C₁ to C₆ alkoxy and the group         L(R)_(n); R²² and R²³ may optionally from a carboxylic ring of 5         or 6 ring members optionally fused with an optionally         substituted benzene and wherein at least one of the substituents         selected from the group of substituents consisting of B and B′,         R²², R²³, R²⁴, R²⁵, R²⁶ and R²⁷ is the group L(R)_(n).

When R²² and R²³ are carbocyclic a preferred compound is of formula XX(d)

where R²², R²⁸ and R²⁹ are as defined for R²² above.

Preferably B and B′ are independently selected from the group consisting of aryl optionally substituted with from 1 to 3 substituents, heteroaryl optionally substituted with from 1 to 3 substituents. The substituents where present are preferably selected from the group consisting of hydroxy, aryl, (C₁ to C₆) alkoxyaryl, (C₁ to C₆) alkylaryl, chloroaryl (C₃ to C₇) cycloalkylaryl, (C₃ to C₇) cycloalkyl, (C₃ to C₇) cycloalkoxy, (C₃ to C₇) cycloalkoxy, (C₁ to C₆) alkyl, aryl (C₁ to C₆) alkyl, aryl (C₁ to C₆) alkoxy, aryloxy, aryloxyalkyl, aryloxy (C₁ to C₆) alkoxy, (C₁ to C₆) alkylaryl, (C₁ to C₆) alkyl, (C₁ to C₆)) alkoxyaryl, (C₁ to C₆) alkyl, (C₁ to C₆) alkoxyaryl, (C₁ to C₆) alkyl, (C₁ to C₆) alkoxyaryl, (C₁ to C₆) alkoxy, amino, N—(C₁ to C₆) alkyl ipirazino, N-aryl piperazino, indolino, piperidino, aryl pipersillins, morpholino, thiomorpholino, tetrahydro quinolino.

NR²⁹R³⁰ wherein R²⁹ and R³⁰ are independently selected from the group selected from C₁ to C₆ alkyl, phenyl, C₅ to C₇ cycloalkyl and the group wherein R²⁹ and R³⁰ form a linking group of 4 or 5 linking groups comprising methylene groups and optionally containing one or two hetero atoms and optionally further substituted by C₁ to C₃ alkyl and the group L(R)_(n).

-   -   R²² is selected from the group consisting of hydrogen, C₁ to C₆         alkyl; COW         where     -   W is OR²⁵ wherein R²⁵ C₁ to C₆ alkyl; and the group NR²⁶R²⁷;         wherein R²⁶ and R²⁷ are independently C₁ to C₆ alkyl; and the         group L(R)_(n).

Particularly referred naphthopyran compounds are of formula XX(a)

wherein R²⁰ and R²¹ are independently selected from the group consisting of hydrogen, hydroxy, alkoxy, amino, alkylamino, dialkylamino and L(R)_(n);

-   -   R²² is the group COW where W is C₁ to C₆ alkoxy or the group         L(R)_(n);     -   R²³ is selected from the group consisting of hydrogen and         NR²⁶R²⁷ where R²⁶ are independently selected from the group         consisting of C₁ to C₆ alkyl and where R²⁶ and R²⁷ may together         form an alkylene group of 4 to 6 carbon atoms;     -   R²⁴ is hydrogen or the group L(R)_(n); and wherein at least one         of R²² and R²⁴ is L(R)_(n).

Specific example of the naphthopyran compounds of formula XX(a) include those shown in Table 3: R²⁰ R²¹ R²² R²³ R²⁴ OCH₃ H CO₂CH₃ H 6-O(CO)(CH₂)₁₀(SiMe₂O)₁₀Si(CH₂)₃CH₃ OCH₃ OCH₃ 002CH₃ H 6-O(CO)(CH₂)₁₀(SiMe₂O)₁₀Si(CH₂)₃CH₃ (CH₃)₂N (CH₃)₂ CO₂CH₃ H 6-O(CO)(CH₂)₁₀(SiMe₂O)₁₀Si(CH₂)₃CH₃ N (CH₃)₂N H —(CO)O(CH₂)₂ 9-(CH₃)₂NH H O(CO)(CH₂)₁₀(SiMe₂ O)₁₀Si(CH₂)₃CH₃ (CH₃)₂N H CO₂CH₃

6-O(CO)(CH₂)₁₀(SiMe₂O)₁₀Si(CH₂)₃CH₃ (CH₃)₂N H CO₂CH₃ H 6-OCO(CH₂)₂CO₂(EO)₁₆CH₃ 4- H CO₂CH₃ H H O(CO)(CH₂)₁₀ (SiMe₂O)₁₀ Si(CH₂)₃CH₃

Compounds of formula XX wherein R²³ and/or R²⁴ comprise the oligomer group L(R)_(n) may be prepared from a suitably substituted acetophenone, benzophenone or benzaldehyde of formula XXI(a). In this process the compound of formula XXI(a) (or a polyhydroxy compound where more than one substituent is required) is reacted with an oligomer esterified toluene sulfonate of formula XXI to provide the corresponding oligomer ether of formula XXI(b). The aromatic oligomer ether of formula XXI(b) is reacted with an ester of succinic acid such as the dialkyl succinate of formula XXI(c). A Stobbe reaction produces the condensed half ester of formula XXII which undergoes cyclo dehydration in the presence of acidic anhydride to form the naphthalene oligomer ether of formula XXIII. This compound of formula XXIII may be reacted with acid such as hydrochloride acid and an anhydrous alcohol such as methanol to form the corresponding naphthol shown in formula XXIV which is in turn coupled with the propargyl alcohol of formula XXV to form the oligomer substituted naphthopyran of the invention of formula XX(b).

Alternatively, compounds of formula XX(c) in which at least one of the germinal phenyl groups is substituted by an oligomer may be prepared from the benzophenone of formula XXI(f). In this process the benzophenone substituted with the appropriate hydroxyl groups is reacted with the oligomer ester of toluene sulfonate of formula XXI(e) to form the corresponding oligomer substituted benzophenone of formula XXI(g). The corresponding propargal alcohol of formula XXV(a) is prepared from the benzophenone by reaction with sodium acetylide in a solvent such as THF. This propargal alcohol of formula XXV(a) is coupled with the appropriate substituted naphthol of formula XXIV(b) to form the oligomer substituted naphthopyrane of formula XX(c).

A further option for forming oligomer substituted pyrans of the invention of formula XX(d) in which the oligomer is present in the 5-position of the naphthopyran may utilise the corresponding carboxylated naphthol of formula XXIII(a). In such a process the naphthol of formula XXIII(a) is reacted with an appropriate oligomer of formula XXI(d) (particularly where linking group L comprising oxygen) to provide an oligomer ester of formula XXIV(a). The oligomer naphthol ester of formula XXIV(a) may be reacted with propargyl alcohol of formula XXV to provide the naphtholpyran of formula XX(d) in which the oligomer is present in the five position.

In a further alternative compounds of formula XX wherein R²² comprises the oligomer L(R)_(n) may be formed by reacting a compound of formula XX(e) with an acid chloride or anhydride substituted oligomer to provide a compound of formula:

Examples of fulgides and fulgimides include compounds of formula XXX and more preferably XXXa:

wherein

-   -   Q is selected from the group consisting of optionally         substituted aromatic, optionally substituted heteroaromatic         (where said aromatic/heteroaromatic may be mono or polycyclic         aromatic/heteroaromatic);     -   R³⁰, R³² and R³³ are independently selected from the group         consisting of a C₁ to C₄ alkyl, C₁ to C₄ alkoxy phenyl, phenoxy         mono- and di(C₁-C₄) alkyl substituted phenyl or phen(C₁-C₄)alkyl         and R³² and R³² optionally together form a fused benzene which         may be further substituted;     -   A′ is selected from the group consisting of oxygen or ═N—R³⁶, in         which R³⁶ is C₁-C₄ alkyl or phenyl,     -   B′ is selected from the group consisting of oxygen or sulfur;     -   R³⁴ and R³⁵ independently represents a C₁-C₄ alkyl, phenyl or         phen(C₁-C₄) alkyl or one of R³⁴ and R³⁵ is hydrogen and the         other is one of the aforementioned groups, or R³⁴R³⁵=represents         an adamantylidene group;     -   and wherein at least one of R³⁰, R³¹, R³², R³⁵ and R³⁶ is the         group L(R)_(n).

When B is NR³⁰ then A¹ is generally oxygen.

Specific examples of compounds of formula XXX include those shown in the following Table 4: No. A′ B′ R³⁰ R31, R³² R³³ R³⁴ R³⁵ 1 O O CH₃ CH₃, CH₃ CH₃ CH₃ CH₃ 2 O O CH₃

CH₂C₆H₄OCO (POS) CH₃ CH₃ 3 O O CH₃ H, CH₃ CH₃ CH₃ CH₃ 4 N—CH₂CH₃ O CH₃ H, CH₃ CH₃ CH₃ CH₃ 5 O O CH₃ H, CH₃ CH₃ CH₃ CH₃ 6 O O CH₃ H, C₆H₅ C₆H₅ CH₃ CH₃ 7 O O CH₃ H, CH₃ CH₃ H C₆H₅O (POS) 8 O NCH₃ CH₃ H, CH₃ CH₃ CH₃ CH₃ 9 NC₆H₄OCO O CH₃ H, CH₃ CH₃ CH₃ CH₃ (POS) 10 O NC₆H₅CH₃ CH₃ H, CH₃ CH₃ CH₃ CH₃ 11 O NC₆H₅ CH₃ H, C₆H₅ CH₃ CH₃ CH₃ 12 O NC₆H₅ CH₃ H, CH₃ CH₃ Cyclopropyl cyclopropyl POS is —(CH₂)₁₀(SiMe₂O)₁₀Si(CH₂)₃CH₃

The fulgides and fulgimides comprising oligomer substituents in accordance with the invention may be particularly useful in molecular switches.

The fulgides and fulgimides of formula XXX may be formed in accordance with procedures similar to those described in U.S. Pat. No. 4,220,708. Fulgides of formula XXX(a) in which the group A- is oxygen may be prepared from five membered heterocycle of formula XXX by reaction with an ester of succinic acid of formula XXXII wherein R³⁷ is a residue of an alcohol, by a Stobbe condensation reaction. Hydrolysing the half ester product of XXXIII formed in the reaction provides the diacid of XXXIII wherein R³⁷ is hydrogen. Heating of the diacid of formula XXXIII yields the succinic anhydride product of formula XXXIII(a). The Stobbe condensation may be carried out by refluxing in t-butanol containing potassium t-butoxide or with sodium hydride in anhydrous toluene. Compounds of the invention of formula XXX(b) in which A- of formula XXX is N-36 may be prepared from the compound of XXX(a) by heating the anhydride and a primary amine R³⁶NH₂ to produce the corresponding half amide which can in turn be cyclised to form the imide of formula XXX(b) for example by heating with an acid chloride or acid anhydride. Alternatively the half ester Stobbe condensation product of formula XXX can be converted to the imide of XXX(b) by reaction with a compound of formula R³⁶NHMgBr to produce the corresponding succinamic acid which may be dehydrated with an acid chloride to provide the compound of formula XXX(b). Compounds of formula XXX(b)

wherein R³⁶ comprises an oligomer group are particularly preferred.

Compounds of formula XXXI wherein R³⁰ includes the oligomer L(R)_(n) may be prepared by reaction of an oligomer acid chloride such as (XXXV) with the appropriate furon in the presence of a Lewis acid catalyst (such as tin tetrachloride): ClCO(CH₂)₁₀(Si(Me)₂O)₁₀(CH₂)₃CH₃  (XXXV)

Fulgimide compounds of formula XXX in which

-   -   A′ is the group of formula XXXVI may be prepared by reaction of         an amine with a free nucleophilic group such as 4-hydroxyaniline         with the corresponding fulgide of formula XXX where A′ is oxygen         to provide the intermediate fulgimide having a free nuclophilic         group such as hydroxy (eg formula XXXVII) and reaction of the         free nucleophilic of the fulgimide with the oligomer acid         chloride or anhydride (such as formula XXXV) to provide the         oligomer substituted fulgimide of (eg formula XXXVI).

The compounds of the invention tend to be oils. This makes them more soluble in monomers and polymer matrices. It also means they are less likely to crystallise in the matrix, thus this may allow higher loading of dyes and may also prevent the crystallisation that may occur with conventional photochromic dyes.

Photochromic compounds of the invention comprising a dialkyl siloxane oligomer may be prepared by anionic polymerization of the appropriate halo-substituted photochoromic moiety.

For example a chlorinated photochromic may be functionalised with a dialkyl siloxane as follows:

An alternative method for oligomer growth on a photochromic moiety is the ATRP and RAFT method or other living polymer growth methods.

This general method of growing oligomers from living initiation sites on the photochromic moiety provides a controlled growth process which may be adapted to use with a wide range of photochromic moieties. Furthermore it will be understood that a range of living polymerisation methods including anionic, ATRP and RAFT may be chosen depending on the types oligomers to be prepared.

Examples of azo dyes include compounds of formula XL

wherein: R⁴⁰ and R⁴¹ are independently selected from the group consisting of hydrogen, C₁ to C₆ alkyl, C₁ to C₆ alkoxy, —NR⁴²R⁴³ wherein R⁴² and R⁴³ are as defined for R²⁶ and R²⁷ aryl (such as phenyl) aryl substituted with one or more substituents selected from C₁ to C₆ alkyl and C₁ to C₆ alkoxy, substituted C₁ to C₆ alkyl wherein the substituent is selected from aryl and C₁ to C₆ alkoxy, substituted C₁ to C₆ alkoxy wherein the substituent is selected from C₁ to C₆ alkoxy aryl and aryloxy.

Specific examples of azo dyes include the following compounds of formula XL: R⁴⁰ R⁴¹ H OCO(CH₂)₂COOCH₂(CF₂)₉CF₃ OCH₃ OCO(CH₂)₂OCO(CH₂)₁₀(SiMe₂O)₁₀SiMe₂C₄H₉

The compounds of the invention tend to be oils. This makes them more soluble in monomers and polymer matrices. It also means they are less likely to crystallise in the matrix, thus this may allow higher loading of dyes and may also prevent the crystallisation that may occur with conventional photochromic dyes.

The compounds of the invention have their own built-in nanoenvironment because the dye can never be separated from a favourable oligomer.

The compounds of the invention may contain one or more photochromic dyes. The compounds of the invention may also be used in mixtures with conventional photochromics.

The use of compounds of the invention allows the fade speed of the photochromic to be changed without changing its colour. Thus it allows the tuning of fade speed for different coloured dyes. This is important to get a consistent colour when fading occurs. Thus, if a blue dye of a particular speed is needed, modification can be made to include an oligomer of an appropriate length in accordance with the invention.

The photochromic compounds (or compositions containing same) of the present invention may be applied or incorporated into a host material by methods known in the art. Such methods include dissolving or dispersing the compound in the host material. The compound may be melt blended with the host matrix.

Imbibation of the photochromic compound into the host material, by immersion, thermal transfer, or coating, and incorporation of the photochromic layer as part of a separation layer between adjacent layers of the host material. The term “imbibation” or “imbibe” is intended to mean and include diffusion of the photochromic compound alone into the host material, solvent assisted diffusion, absorption of the photochromic compound into a porous polymer, vapor phase transfer, and other such transfer mechanisms. For example:

-   -   (a) The photochromic compounds (or compositions containing same)         of the present invention can be mixed with a polymerizable         composition that, upon curing, produces an optically clear         polymeric host material and the polymerizable composition can be         cast as a film, sheet or lens, or injection molded or otherwise         formed into a sheet or lens;     -   (b) The photochromic compounds of the present invention can be         dissolved or dispersed in water, alcohol or other solvents or         solvent mixtures and then imbibed into the solid host material         by immersion for from several minutes to several hours, eg, 2-3         minutes to 2-3 hours for the host material in a bath of such         solution or dispersion. The bath is conventionally at an         elevated temperature, usually in the range of 50° C. to 95° C.         Thereafter, the host material is removed from the bath and         dried;     -   (c) The photochromic compounds (and compositions containing the         same) may also be applied to the surface of the host material by         any convenient manner, such as spraying, brushing, spin-coating         or dip-coating from a solution or dispersion of the photochromic         material in the presence of a polymeric binder. Thereafter, the         photochromic compound is imbibed by the host material by heating         it, eg, in an oven, for from a minute to several hours at         temperatures in the range of from 80° C. to 180° C.;     -   (d) In a variation of the above imbibation procedure, the         photochromic compound or composition containing the same can be         deposited onto a temporary support, or fabric, which is then         placed in contact with host material and heated, eg, in an oven;     -   (e) The photochromic compounds can be dissolved or dispersed in         a transparent polymeric material which can be applied to the         surface of the host in the form of a permanent adherent film or         coating by any suitable technique such as spraying, brushing,         spin-coating or dip-coating;     -   (f) The photochromic compounds can be incorporated or applied to         a transparent polymeric material by any of the above mentioned         methods, which can then be placed within the host material as a         discrete layer intermediate to adjacent layers of a host         material(s);     -   (g) The photochromic adduct of the invention may be incorporated         into a dye composition by ball milling with a carrier to         disperse it in a binder matrix. Such a composition may be used         as an ink, for example in ink jet printing and suitable (PC)         moieties may be chosen to allow security markings on documents         to be visible on exposure to UV light used in photocopy;     -   (h) The photochromic compound may be compounded with suitable         resins and the resin melted to shape it to form a film, for         example by blow moulding or to form more complex extruded         shapes, e.g. by injection moulding and/or blown structures.

The transfer method is described, inter alia, in the documents U.S. Pat. Nos. 4,286,957 and 4,880,667. In this technique, a surface of the transparent polymer substrate is coated with a layer of a varnish containing the photochromic substance to be incorporated. The substrate, thus coated, is then treated thermally in order to cause the photochromic substance to migrate into the substrate.

It is a significant advantage of the adduct photochromic of the invention that they are relatively stable even at elevated temperature. In contrast attempt made to improve fade results using unsaturated functional groups result in compounds which polymerise at elevated temperature and must generally be stored to avoid premature polymerisation.

The present invention is more particularly described in the following examples which are intended as illustrative only since numerous modifications and variations therein will be apparent to those skilled in the art.

Examples of host materials that may be used with the photochromic compounds of the present invention include polymers, i.e., homopolymers and copolymers of polyol(allyl carbonate) monomers, homopolymers and copolymers of polyfunctional acrylate monomers, polyacrylates, poly(alkylacrylates) such as poly(methylmethacrylate), cellulose acetate, cellulose triacetate, celluslose acetate propionate, cellulose acetate butyrate, poly(vinyl acetate), poly(vinylalcohol), poly(vinylchloride), poly(vinlylidene chloride), polyurethanes, polycarbonates, poly(ethylene-terephthalate), polystyrene, copoly(styrene-methylmethacrylate), copoly(styrene-acrylateonitrile), poly(vinylbutryal), and homopolymers and copolymers of diacylidene pentaerythritol, particularly copolymers with polyol(allylcarbonate) monomers, e.g. diethylene glycol bis(allyl carbonate), and acrylate monomers. Transparent copolymers and blends of the transparent polymers are also suitable as host materials.

The host material may be an optically clear polymerized organic material prepared from a polycarbonate resin, such as the carbonate-linked resin derived from bisphenol A and phosgene which is sold under the trademark LEXAN; a poly(methylmethacrylate), such as the material sold under the trademark PLEXIGLAS; polymerizates of a polyol(allyl carbonate), especially diethylene glycol bis(allyl carbonate), which is sold under the trademark CR-39, and its copolymers such as copolymers with vinyl acetate, eg copolymers of from about 80-90 percent diethylene glycol bis(allyl carbonate) and 10-20 percent vinyl acetate, particularly 80-85 percent of the bis(allyl carbonate) and 15-20 percent vinyl acetate, cellulose acetate, cellulose propionate, cellulose butyrate, polystyrene and copolymers of styrene with methyl methacrylate, vinyl acetate and acrylonitrile, and cellulose acetate butyrate.

Polyol (allyl carbonate) monomers which can be polymerised to form a transparent host material are the allyl carbonates of linear or branched aliphatic glycol bis(allyl carbonate) compounds, or alkylidene bisphenol bis(allyl carbonate) compounds. These monomers can be described as unsaturated polycarbonates of polyols, eg glycols. The monomers can be prepared by procedures well known in the art, eg, U.S. Pat. Nos. 2,370,567 and 2,403,113. The polyol (allyl carbonate) monomers can be represented by the graphic formula:

wherein R is the radical derived from an unsaturated alcohol and is commonly an allyl or substituted allyl group, R′ is the radical derived from the polyol, and n is a whole number from 2-5, preferably 2. The allyl group (R) can be substituted at the 2 position with a halogen, most notably chlorine or bromine, or an alkyl group containing from 1 to 4 carbon atoms, generally a methyl or ethyl group. The R group can be represented by the graphic formula:

wherein R₀ is hydrogen, halogen, or a C₁-C₄ alkyl group. Specific examples of R include the groups: allyl 2-chloroalyl, 2-bromoalyl, 2-fluoroalyl, 2-methylalyl, 2-ethylalyl, 2-isopropylalyl, 2-n-propylalyl, and 2-n-butylalyl. Most commonly R is the allyl group: H₂C═CH—CH₂— R′ is the polyvalent radical derived from the polyol, which can be an aliphatic or aromatic polyol that contains 2, 3, 4 or 5 hydroxy groups. Typically, the polyol contains 2 hydroxy groups, ie a glycol or bisphenol. The aliphatic polyol can be linear or branched and contain from 2 to 10 carbon atoms. Commonly, the aliphatic polyol is an alkylene glycol having from 2 to 4 carbon atoms or a poly(C₂-C₄) alkylene glycol, ie ethylene glycol, propylene glycol, trimethylene glycol, tetramethylene glycol, or diethylene glycol, triethylene glycol etc. In a further embodiment, the invention provides a photochromic article comprising a polymeric organic host material selected from the group consisting of poly(methyl methacrylate), poly(ethylene glycol bismethacrylate), poly(ethoxylated bisphenol A dimethacrylate) thermoplastic polycarbonate, poly(vinyl acetate), polyvinylbutyral, polyurethane, and polymers of members of the group consisting of diethylene glycol bi(allylcarbonate) monomers, diethylene glycol dimethacrylate monomers, ethoxylated phenol bismethylacrylate monomers, diisopropenyl benzene monomers and ethoxylated trimethylol propane triacrylate monomers, and a photochromic amount of a compound of the invention.

The polymeric organic host material is selected from the group consisting of polyacrylates, polymethacrylates, poly(C₁-C₁₂) alkyl methacrylates, polyoxy(alkylene methacrylates), poly(alkoxylates phenol methacrylates), cellulose acetates, cellulose triacetate, cellulose acetate propionate, cellulose acetate butyrate, poly(vinyl acetate), poly(vinyl alcohol), poly(vinyl chloride) poly(vinylidene chloride), thermoplastic polycarbonates, polyesters, polyurethanes, polythiourethanes, poly(ethylene terephthalate), polystyrene, poly(alpha methylstyrene), copoly(styrene-methylmethacrylate), copoly(styrene-acrylonitrile), polyvinylbutyral and polymers of members of the group consisting of polyol(allyl carbonate) monomers, polyfunctional acrylate monomers, polyfunctional methylacrylate monomers, diethylene glycol dimethacrylate monomers, diisopropenyl benzene monomers, alkoxylates polyhydric alcohol monomers and diallylidene pentaerythritol monomers.

The photochromic article may comprise a polymeric organic material which is a homopolymer or copolymer of monomer(s) selected from the group consisting of acrylates, methacrylates, methyl mathacrylate, ethylene glycol bis methacrylate, ethoxylated bisphenol A dimethacrylate, vinyl acetate, vinylbutyral, urethane, thiourethane, diethylene glycol bis(allyl carbonate), diethylene glycol dimethacrylate, diisopropenyl benzene, and ethoxylated trimethyl propane triacrylates.

The photochromic composition of the invention may contain the photochromic compound in a wide range of concentrations depending on the type of photochromic moiety and its intended application. For example in the case of inks in which high colour intensity is required a relatively high concentration of up to 30 wt % photochromic may be required. On the other hand it may be desirable in some cases such as optical articles to use photochromics in very low concentrations to provide a relatively slight change in optical transparency on irradiation. For example, as low as 0.01 mg/g of host resin may be used. Generally the photochromic resin will be present in an amount of from 0.01 mg/g of host resin up to 30 wt % of host resin. More preferably the photochromic compound will be present in an amount of from 0.01 mg/g to 100 mg/g of host matrix and still more preferably from 0.05 mg/g to 100 mg/g of host matrix.

The photochromic article may contain the photochromic compound in an amount of from 0.05 to 10.0 milligram per square centimetre of polymeric organic host material surface to which the photochromic substance(s) is incorporated or applied.

The compounds of the invention may be used in those applications in which the organic photochromic substances may be employed, such as optical lenses, eg, vision correcting ophthalmic lenses and plano lenses, face shields, goggles, visors, camera lenses, windows, mirrors, automotive windshields, jewelry, aircraft and automotive transparencies, e.g., T-roofs, sidelights and backlights, plastic films and sheets, textiles and coatings, e.g. coating compositions. As used herein, coating compositions include polymeric coating composition prepared from materials such as polyurethanes, epoxy resins and other resins used to produce synthetic polymers; paints, i.e., a pigmented liquid or paste used for the decoration, protection and/or the identification of a substrate; and inks, i.e., a pigmented liquid or paste used for writing and printing on substrates, which include paper, glass, ceramics, wood, masonry, textiles, metals and polymeric organic materials. Coating compositions may be used to produce verification marks on security documents, e.g. documents such as banknotes, passport and driver' licenses, for which authentication or verification of authenticity may be desired. Security documents, for indicating exposure to light during photocopying.

Throughout the description and claims of this specification, use of the word “comprise” and variations of the word, such as “comprising” and “comprises”, is not intended to exclude other additives, components, integers or steps.

The discussion of documents, acts, materials, devices, articles and the like is included in this specification solely for the purpose of providing a context for the present invention. It is not suggested or represented that any or all of these matters formed part of the prior art base or were common general knowledge in the field relevant to the present invention as it existed in Australia before the priority date of each claim of this application.

EXAMPLES Note on poly(ethylene glycol) {PEG} methyl ethers and polydimethylsiloxane oligomers and naming of compounds

The PEG mono methyl ethers are supplied with an average molecular weight. For example the Aldrich Chemical Company supplies them with average number molecular weights such as 350, 750 etc which approximately but not exactly correspond to 7 PEG units, 16 PEG units etc. Thus the 350 Mn PEG contains a distribution of molecular weights and therefore PEG units. Similar comments can be made about the PDMS oligomers. They are supplied with an average molecular weight. Any number quoted as the number of repeat units of dimethyl siloxane is to be interpreted as an average value. To avoid cumbersome and strictly inaccurate naming, the PEG derivatives will be named on the basis of the Mn of the PEG from which they are derived. The succinic acid derivative from 350 PEG will be “succinic acid mono-PEG(350) ester” and not the formal “Succinic acid mono-(2-{2-[2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethyl)ester” which does not indicate the distribution of chain lengths that exists. Succinic acid mono-PEG(350) ester

Poly(ethylene glycol) methyl ether (ie PEG(350) ca 7-PEG unit, Mn ca. 350 g/mol) (20 g, 57.1 mmoles) was dissolved in 50 mL of dichloromethane together with succinic anhydride (5.7 g, 57 mmoles), methanol (100 mg) and dimethylaminopyridine (50 mg) at room temperature under argon. Triethylamine (7.9 mL, 5.7 g, 57.1 mmole) was added dropwise. The reaction was stirred at room temperature for one day and then refluxed for one hour. The reaction was worked up by dilution with dichloromethane, then washed with 2 M HCl and then brine before evaporation under vacuum to give a clear oil as product (19 g, 74%). ¹H NMR (CDCl₃) δ 2.55 (s, 4H, C═O—CH₂CH₂—C═O), 3.25 (s, 3H, methyl), 3.45 (mult, 2H), 3.55 (s, 22H, PEGs), 3.60 (mult, 2H, CH₂CH₂—OC═O), 4.15 (mult, 2H, CH₂—OC═O) ppm. ¹³C NMR (CDCl₃) 28.8 & 29.1 (succinyl methylenes), 58.9 (—OCH₃), 63.8 & 68.3 (CH₂CH₂—OC═O), 70.4 (most PEG units), 71.8 (—CH₂—O—CH₃), 172.2 (ester), 175.0 (acid) ppm. Succinic acid mono-PEG(750) ester

Succinic acid mono-PEG(750) ester was synthesised in a similar manner to succinic acid mono-PEG(350) ester. Yield 79%. ¹H NMR (CDCl₃) δ 2.50 (s, C═O—CH₂CH₂—C═O), 3.25 (s, methyl), 3.50 (s, PEGs), 4.10 (mult, CH₂—OC═O) ppm. ¹³C NMR (CDCl₃) 28.7 & 29.0 (succinyl methylenes), 58.9 (—OCH₃), 63.7 and 68.9 (CH₂CH₂—OC═O), 70.4 (most PEG units), 71.8 (—CH₂—O—CH₃), 172.1 (ester), 174.4 (acid) ppm. Succinic acid chloride mono-PEG(350) ester

The succinic acid mono-PEG(350) ester (9 g, 20 mmoles) was dissolved in dichloromethane (10 mL) at room temperature under argon and thionyl chloride (3.5 mL) was added dropwise and the reaction stirred for 5 days and then heated at 50-70° C. for 2 hours. The reaction was evaporated under vacuum for one hour at 60° C. The oil was pure acid chloride (9.22 g, 98%). ¹H NMR (CDCl₃) δ 2.55 (t, 2H, CH₂—C═O—Cl), 3.17 (t, 2H, O—C═O—CH₂), 3.31 (s, 3H, methyl), 3.50 (mult, 2H), 3.60 (s, 22H, PEGs), 4.22 (mult, 2H, CH₂—OC═O) ppm. ¹³C NMR (CDCl₃) 29.3 & 41.7 (succinyl methylenes), 59.0 (—OCH₃), 64.2 & 68.9 (CH₂CH₂—OC═O), 70.5 (most PEG units), 71.9 (—CH₂—O—CH₃), 170.9 (ester), 172.9 (acid chloride) ppm. Succinic acid chloride mono-PEG(750) ester

Succinic acid chloride mono-PEG(750) ester was synthesised in the same manner as described for succinic acid chloride mono-PEG(350) ester. Yield 98%. ¹H NMR (CDCl₃) δ 2.52 (t, CH₂—C═O—Cl), 3.03 (t, 2H, O—C═O—CH₂), 3.16 (s, methyl), 3.34 (small mult), 3.44 (s, 22H, PEGs), 3.51 (small mult.), 4.06 (mult, CH₂—OC═O) ppm. Numbering of Spiro-Oxazines

This moiety will be referred to hereinafter by the abbreviation “SOX”.

The examples are described in part with reference to the drawings (see Examples 8, 23 and 24).

In the drawings:

FIG. 1 is a thin film analysis in polymethyl methacrylate matrix comparing the absorbance of the photochromic dyes of Examples 2, 5 and CE1 with the parent dye.

FIG. 2 is the normalised absorbance of compositions referred to in FIG. 1.

FIG. 3 is a thin film analysis graph comparing the absorbance over time of photochromic dyes of CE1, Example 5 and Example 2 with the parent dye in a polystyrene matrix.

FIG. 4 is a thin film analysis graph sharing the normalised absorbance of the system referred to in FIG. 3.

FIG. 5 is an ROE experiment referred to in Example 1.

FIG. 6 is an ROE experiment of the compound of Example 5.

FIG. 7 is an ROE nmr experiment providing evidence of nano solvation/encapsulation in the compound of Example 5.

FIG. 8 is an absorbance graph showing colouration and fade speeds of compound of Example 5.

FIG. 9 is a normalised absorbance graph of the test set up referred to in FIG. 8.

FIG. 10 is an absorbance graph showing the colouration and fade speed of the compound of Example 16.

FIG. 11 is a normalised absorbance graph of the set up referred to in FIG. 10.

FIG. 12 is an absorbance graph showing the colouration and fade speed of the compound of Example 20.

FIG. 13 is a normalised absorbance graph of the set up described for FIG. 12.

FIG. 14 is an absorbance graph showing the colouration and fade speed of the dyes of Example 5 and CE3.

FIG. 15 is a normalised absorbance graph of the set up described for Example 14.

FIG. 16 is an absorbance graph comparing the rate of colouration and fade of the dye of Example 9 with the “Spectrolite Velocity Transitions” product.

Example 1 9′-(PEG(350)-succinyl)-1,3,3-trimethylspiro[indoline-2,3′-[3h]naphtha[2,1-b][1,4]oxazine] (PEG(350)-suc-SOX)

9′-Hydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]naphtha[2,1-b][1,4]oxazine] (1.95 g, 5.67 mmoles) and triethylamine (0.857 g, 1.18 mL, 8.5 mmoles) were added together in dichloromethane (30 mL) and then the succinic acid chloride mono-PEG(350) ester (3.19 g, 6.8 mmol) in dichloromethane was added dropwise to the solution at room temperature under argon protection. When the reaction was complete it was worked up by dilution with dichloromethane, washing with dilute sodium hydroxide, dilute HCl, and brine before final drying with magnesium sulphate to give a dark brown oil (4 g) which was purified by column chromatography to give a brown oil. ¹H NMR (CDCl₃) δ 1.33 (s, 6H, C(CH₃)₂), 2.75 (s, 3H, N—CH₃), 2.82 & 2.94 (mults, 4H, C═O—CH₂CH₂—C═O), 3.35 (s, 3H, O—CH₃), 3.53 (mult, 2H, CH₂—O—CH₃), 3.63 (s, PEG units), 3.71 (mult, 2H, CH₂CH₂O—C═O), 4.30 (mult, 2H, CH₂CH₂O—C═O), 6.58 (d, J=7.6 Hz, 5-H), 6.82-7.27, 7.59-7.79, 8.23 (d, H=2.7 Hz, 7′-H) ppm.

Example 2 9′-(PEG(750)-succinyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]naphtha[2,1-b][1,4]oxazine] (PEG(750)-suc-SOX)

9′-(PEG(750)-succinyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]naphtha[2,1-b][1,4]oxazine] was synthesised in the same manner as 9′-(PEG(350)-succinyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]naphtha[2,1-b][1,4]oxazine] using succinic acid chloride mono-PEG(750) ester in place of succinic acid chloride mono-PEG(350) ester to give 76% yield of product. The ¹H NMR spectrum looked the same as 9′-(PEG(350)-succinyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]naphtha[2,1-b][1,4]oxazine] except it had a correspondingly larger singlet for the PEG units at 3.63 ppm. ¹H NMR (CDCl₃) δ 1.33 (s, 6H, C(CH₃)₂), 2.75 (s, 3H, N—CH₃), 2.82 & 2.94 (mults, 4H, C═O—CH₂CH₂—C═O), 3.35 (s, 3H, O—CH₃), 3.53 (mult, 2H, CH₂—O—CH₃), 3.63 (s, PEG units), 3.71 (mult, 2H, CH₂CH₂O—C═O), 4.30 (mult, 2H, CH₂CH₂O—C═O), 6.58 (d, J=7.6 Hz, 5-H), 6.82-7.27, 7.59-7.79, 8.23 (d, H=2.7 Hz, 7′-H) ppm.

Example 3 Part (a) 5,9′-Dihydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]naphtha[2,1-b][1,4]oxazine]

5-Hydroxy-1,2,3,3-tetramethylindolium iodide (1.65 g, 5.2 mmoles) was dissolved in methanol (10 mL) and butanone (5 mL) and piperidine (0.5 mL) were added dropwise and the solution let stand. Then 2,7-dihydroxy-1-nitrosonaphthalene (0.983 g) was added and the solution was refluxed for an hour and then let stir overnight at room temperature. The solvents were evaporated and the residue was chromatographed to give a dark blue product (300 mg 17%). ¹H NMR (DMSO-d₆) □ 1.20 & 1.27 (s, 3H, methyl), 2.57 (s, 3H, N-Me), 6.37-6.61 (mult aromatic), 6.61-6.76 (mult aromatic), 7.58-7.98 (mult. aromatic), 8.80 (naphthyl aromatic), 9.88 (naphthyl aromatic) ppm.

Part (b) 5,9′-Di(PEG(350)-succinyl)-1,3,3-trimethylspiro[induline-2,3′-[3H]naphtha[2,1-b][1,4]oxazine] (BisPEG (350)-suc)-SOX)

5,9′-Di(PEG(350)-succinyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]naphtha[2,1-b][1,4]oxazine] was made in the same way as 9′-(PEG(350)-succinyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]naphtha[2,1-b][1,4]oxazine using 2 molar equivalents of succinic acid chloride mono-PEG(350). The product was a brown oil (90% yield). ¹H NMR (CDCl₃) δ 1.00 (s, 3H, methyl), 1.13 (s, 3H, methyl), 2.38 (s, 3H, N-methyl), 2.49 (mult, 8H, C═O—CH₂CH₂—C═O), 3.10 (s, 6H, O—CH₃), 3.40 (s, ca 12-14 full PEG units+2×½PEG units), 4.12 (s, 4H, CH₂CH₂O—C═O), 6.18 (d, J=8.2 Hz, 5-H), 6.73-7.0 (mult. aromatic), 7.2-7.6 (mult. aromatic), 8.55 & 8.82 (s, naphthyl aromatic) ppm.

Example 4 Poly(dimethylsiloxane) monocarboxydecoyl chloride terminated

Poly(dimethylsiloxane) monocarboxydecyl (MCR-B11 ABCR Mw ca 1056)) (4 g, 4 mmole) was dissolved in 10 mL of dichloromethane, thionyl chloride (2 mL) was added and the reaction heated under argon overnight. The reaction was worked up by evaporation of solvent and thionyl chloride under vacuum and mild heating (40° C.) to give 3.77 g (94%) of very pale amber oil. ¹H NMR (CDCl3) δ 0.0 (s, Si-Me), 0.45 (m, CH2), 0.8 (t, J=ca. 6.6 Hz, CH3), 1.2 (s, CH2), 1.6 (pent, 2H, CH2-CH2-COCl), 2.8 (t, J=7 Hz, 2H, CH2-CH2-COCl). 13C NMR (CDCl3) δ 0.18, 1.05, 1.18, 1.78, 13.8, 18.0, 18.3, 23.2, 25.07, 25.5, 26.4, 28.5, 29.1, 29.4, 29.48, 33.4, 47.1 (CH2-COCl), 173.7 (COCl) ppm.

Example 5 9′-(PDMS(855)-undecoyl)-1,3,3-trimethylspiro[indoline-2,3′-[3h]naphtha[2,1-b][1,4]oxazine]

9′-Hydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]naphtha[2,1-b][1,4]oxazine] (1 g, 2.9 mmoles) and triethylamine (0.9 mL, 655 mg, 6.5 mmoles) were added together in dichloromethane (20 mL) and then poly(dimethylsiloxane) monocarboxydecoyl chloride terminated (3.0 g, 2.8 mmol) in dichloromethane was added dropwise to the solution at room temperature under argon protection. The reaction was monitored by tlc (DCM or ether:hexane 1:1) and was completed after a few hours. The reaction was worked up by washing with water, brine (plus a little of v dilute HCl to break the emulsion), dried (MgSO4) before evaporation to a dark liquid. The oil was chromatographed on silica with ether:hexane (1:3) to give 2.1 g (52%) of pale brown green oil as the desired product. A second slower fraction (200 mg) was obtained that was spectroscopically similar to the product except it had a vinyl (terminal) group and had much less DMS content. ¹H NMR (acetone-d6) δ=0.09 (d, J=1.8 Hz, Si-Me), 0.10 (d, J=1.83 Hz, Si-Me), 0.12 (d, J=1.8 Hz, Si-Me), 0.13 (s, Si-Me), 0.6 (mult., 4H, alkyl), 0.90 (mult., 4H, alkyl), 1.3-1.4 (mult, 22H, 9,10-H, alkyl, CH2-CH3), 1.50 (mult, 2H, ‘c’-H), 1.80 (pent., J=7.3 Hz), 2H, ‘b’-H), 2.68 (t, J=7.3 Hz, 2H, ‘a’-H), 2.77 (s, 3H, 8-H), 6.65 (d, J=7.8 Hz, 7-H), 6.87 (t, J=7.3 Hz, 5-H), 7.03 (d, J=8.5 Hz, 5′-H), 7.14 (d, J=7.3 Hz, 4-H), 7.19 (apparent t, 2H, 6 & 8′-H), 7.80 (d, J=9.3 Hz, 6′-H), 7.82 (s, 2′H), 7.86 (d, J=8.6 Hz, 7′-H), 8.23 (d, J=2.3 Hz, 10′-H) ppm. MS (FAB), M+ 1368 (100%) (corresponds to 11 DMS units in oligomer), 1145.9 (90%) (corresponds to 8 DMS units in oligomer), 1591.4 (85%) (corresponds to 14 DMS units in oligomer, 923.6 (corresponds to 5 DMS units in oligomer), 1813.5 (corresponds to 17 DMS units in oligomer). Peaks for all other oligomer lengths between 4-19 DMS units were also observed in a small bell curve distribution centred around 12 DMS units (12 MDS 40% of M+ with other peaks being smaller).

Example 6 9′-((1-(Isobutyl)-POSS)-3-propyl)-succinyl)-1,3,3-trimethylspiro[indoline-2,3′-[3h]naphtha[2,1-b][1,4]oxazine]

9-(Monocarboxy-succinyl)-1,3,3-trimethylspiro[indoline-2,3′-[3h]naphtha[2,1-b][1,4]oxazine (0.62 g 1.8 mmoles), hydroxypropylisobutyl-POSS (1.58 g 1.8 mmoles), dimethylaminopyridine (33 mg, 0.2 mmoles) were dissolved in dichloromethane (15 mL) and then dicyclohexylcarbodiimide (0.4 g, 1.8 mmoles) in dichloromethane was added slowly over five minutes. The solution was refluxed under argon for 4-5 hours until tlc analysis showed no starting spirooxazine was present. Product was identified on tlc as a fast moving band (ether:hexane 1:1 rf ca. 0.8). The reaction was worked up by dilution with dicholoromethane (to 100 mL), cooling and filtering off the precipitated dicyclohexyl urea. The solution was washed with water, brine, dried and evaporated to give a white solid. This was chromatographed on silica (ether:hexane 1:3) until the fast moving light blue band was eluted. The solvent was evaporated from the collected band to give a white/pale green/blue solid (0.86 g, 37%). The column was eluted with ether:hexane (1:1) to give two more bands. These were evaporated to give a smear and a non-photochromic solid. The material was purified by reverse phase chromatography to give a crystalline material that displayed photochromism in the crystalline state. It turned blue when irradiated with ultra violet light. MS (IE) 1302 (M+, 100%). δ≠0.65 (14H, dd J 2.19, 6.95), 0.75 (2H, t J 8.23), 0.98 (42H, bs), 1.34 (3H, s), 1.36 (3H, s), 1.75-1.97 (9H, m), 2.77 (3H, s), 2.80 (2H, t J 6.40) 3.0 (2H, t J 6.40), 4.12 (2H, t J 6.79), 6.66 (1H, d J 7.68), 6.87 (1H, dd J 0.73, 7.32), 7.05 (1H, d J 8.78), 7.15 (1H, d J 7.32), 7.17-7.22 (2H, m), 7.82 (1H, d J 8.78), 7.83 (1H, s), 7.88 (1H, d J 8.78), 8.26 (1H, d J 2.38) ppm.

Example 7

A simple screen for examining photochromic speed was carried out as follows:

A small quantity of the photochromic compound was dissolved in THF to give a concentration of ca 25 mmol per millilitre. This solution was then dropped onto normal photocopy paper (brand “Reflex”) to give a spot of about 1-2 cm in diameter. This was allowed to dry. The spot was then irradiated with a hand held UV light (365 nm) and the spot would colorize and then decolorize when the UV light was removed. When spots of the parent SOX, CE1, Example 1, and Example 2 were examined simultaneously it was obvious to the eye that the Example 1 and Example 2 decolourised in less than 15 seconds whereas the conventional dyes (parent SOX and CE1) were still decolourising after 5 minutes. In addition, the conventional dyes would fatigue after 3-4 hours such that no colouration was observed after about 4 hours. However, the Example 1 and Example 2 dyes were protected from fatigue for an extended period. Typically, photochromism was observed for at least a week.

Example 8

Steady state UV-Visible absorption measurements in Table 5 were collected using a Varian Cary 50 UV-visible Spectrophotometer. The instrument allows for the in-situ excitation of samples and hence the study of “real-time” changes in absorption of solutions and films. The Cary 50 is equipped with a thermostatted peltier sample holder allowing an operating temperature range of −10°-100° C.

FIG. 17 Instrumental setup for irradiation and absorption measurements of photochromic samples. A number of filters can be integrated into the system to select for ranges of wavelengths exciting the sample. Equally, a monochromator can also be incorporated between the 2 lenses to select for wavelength.

Samples were photoexcited by exposure to a 150 W Xenon Arc lamp. The excitation wavelength range was restricted to approximately 300-400 nm and above 650 nm by the use of two optical filters, WG 320 and 9863 (see FIG. 18).

A water filter was also used to reduce thermal heating of the sample.

Films of the photochromic compounds (approximately 0.3 g.L⁻¹) were cast from a 4% w/v solution of polymer dissolved in a suitable solvent onto glass slides and air dried. Films were approximately 100°m thick.

Film samples were mounted in the spectrophotometer with a particular geometry (see FIG. 19). The face of the film was pointing away from the detector to minimise scattered excitation light saturating the detector. Another cut-off filter (GG495) was used immediately in front of the detector to further minimise scattered UV light reaching the detector.

FIG. 18: Transmission spectra of the filters employed in the experimental setup.

FIG. 19: Top view of the Cary 50 sample holder and experimental setup geometries for films.

Samples were allowed to thermally equilibrate at each temperature for about five minutes before scans were performed.

The absorbance (A₀), the half lives for discolouration (t_(1/2), sec) and the three quarter lives (t_(3/4), S) for discolouration for several photochromic compounds in different polymer films are given in Table 5. T_(1/2) is the time taken for the optical density to reduce by half from the initial maximum optical density of the coloured from when UV irradiation is stopped. T_(3/4) is time taken for the optical density to reduce by three quarters from the initial maximum optical density of the coloured form of the dye from when UV irradiation is stopped. TABLE 5 2 Oxford Blue 0.218 63 302 0.196 91 473 0.231 193 1128 [N-isobutyl- SOX) 3 PEG(350)- 0.201 58 233 0.222 46 270 0.200 144 922 SOX (Example 1) 4 PEG (750)- 0.253 44 228 0.153 39 247 0.195 93 614 SOX (Example 2) 5 Bis Propyl- 0.155 110 555 0.046 207 1284 0.191 367 2663 SOX 6 Bis PEG 0.237 83 382 0.115 49 402 0.143 412 2534 (350)-SOX (Example 3)

Examples of the control of the fade speed by choice of oligomer and matrix can be seen in Table 5. Rows 3 and 4 show the fade enhancement of spirooxazine photochromic agents functionalised by polar polyethylene gycol (PEG) chains of increasing length respectively. Example 2 shows enhanced fade speed relative to reference compounds in rows 1 and 2 in poly(methyl methacrylate), poly(styrene) and poly(carbonate). Furthermore it is apparent that the longer the oligomer length, the better the encapsulation effect with Example 2 (row 4) fading faster than Example 1 (row 3) in all three polymers. PEG(750) has approximately 16 PEG units while PEG(350) has approximately 7. In this case of Example 2 the fade speed has almost become independent of the host matrix.

The encapsulation effect can be seen clearly in the case of Example 3 (Table 5 row 6). Here the fade speed in poly(styrene) is significantly faster than poly(methylmethacrylate) as the PEG chains will be incompatible with the polystyrene matrix and coil close to or encapsulate the photochromic. The poly(styrene) fade speed is similar to that of Example 1. However, in polymethyl methacrylate the PEG chains of Example 3 are more compatible with the matrix and the T_(1/2) fade speed slows to be significantly slower as Example 1. The bis-propylate-SOX also shows this effect with a short alkyl chain. Here the non-polar alkyl chain will be incompatible with polar poly(methyl methacrylate) matrix but more compatible with non-polar poly(styrene) and so fade speed is much slower in poly(styrene). Both Example 3 and bis-propyl-SOX show very slow fade speed in polycarbonate.

Kinetic Curves

The following kinetic curves (FIGS. 1 to 4) were obtained using different films and under different conditions to those used for acquiring the data in Table 5. The experimental set up used is described in Example 24. The curves show the dramatic effect of the PDMS oligomer attached to a photochromic dye on fade speed of the photochromic dye It provides solution-like kinetic behaviour not previously observed for a photochromic dye in a polymer matrix. It allows rapid colouration to a constant maximum optical density followed by a rapid fade on cessation of irradiation. Similar effects are found with the PEG oligomer in Example 2 (SOX-suc-PEG(750)). When it is placed in a matrix that the PEG will have some incompatibility [ie polystyrene] the PEG then is more available to solvate the photochromic dye and a fast fade is observed. CE1 (SOX-propylate) is electronically identical to both the Example 5 (SOX-undec-PDMS (855)) and Example 2 (SOX-suc-PEG(750)) and shows dramatically slower colouration and fade kinetics as there is no oligomer to provide a favourable switching environment.

The following curves (FIG. 1 to 4) show the colouration and fade performance of the Example 2 (SOX-suc-PEG(750)), Example 5 (SOX-undec-PDMS (855)) in comparison with the electronically identical SOX-Propylate and parent dye (no substituents) in poly(methylmethacrylate) and poly(styrene) respectively. They show that the PDMS oligomer allows the dye to rapidly colourise and achieve a maximum optical density within tens of seconds. Conventional dyes like the CE1 (SOX-propylate) (which is electronically identical to the Example 5 (SOX-undec-PDMS (855)) and parent SOX (1,3-dihydro-1,3,3-trimethyl-spiro[2H-indole-2,3′-[3H]-naphth[2,1-b][1,4]oxazine]) typically colourise slowly and continue to do so even after 100 seconds.

The normalised fade curves focus on the fade kinetics. It is obvious to the eye that the Example 5 (SOX-undec-(PDMS(855)) undergoes fade far faster than any of the conventional dyes and reaches low if not actually 0.0 absorbance within a minute whereas the conventional dyes still have significant absorbance after 1000 secs and longer.

The PDMS is providing a highly mobile local environment for switching behaviour. Without wishing to be bound by theory it is thought that its incompatibility with the matrix allows it to aggregate near or around the dye and so provides protection from the rigidity of the bulk matrix. This occurs in poly(styrene), poly(methylmethacrylate) and poly(carbonate) where it shows the same behaviour in all the matrices. The behaviour of the dye is similar to that observed in solution. It shows rapid coloration with an initial overshoot and then rapidly reaches a constant optical density, shows un-damped kinetic behaviour and then rapid fade when irradiation stops.

Example 9 5-(PDMS(855)-undecoyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine]

5-(PDMS(855)-undecoyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] was synthesised according to the procedure for the preparation of 9′-(PDMS(855)-undecoyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] (Example 5) using 5-hydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] in place of 9′-hydroxy-1,3,3-trimethylspiro [indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine], column chromatography (silica) 1:20, ethyl acetate:hexane (51%). ¹H NMR(C₂D₆O) δ≠0.1 (bs), 0.58 (4H, m), 0.89 (4H, m), 1.21-1.52 (242H, m), 1.72 (2H, m), 2.55 (2H, t, J 7.31), 2.76 (3H, s), 6.63 (1H, d, J 9.14), 6.88 (1H, d, J 2.19), 6.92 (1H, d, J 2.19), 7.07 (1H, d, J 8.77), 7.42 (1H, dd, J 8.41, 1.46), 7.59 (1H, dd, J 8.41, 1.46), 7.74-7.88 (3H, m), 8.85 (1H, d, J 8.41) ppm. ¹³C NMR (C₂D₆O) δ≠172.8, 151.5, 146.1, 145.6, 144.8, 137.8, 131.8, 131.2, 130.4, 128.7, 127.8, 125.0, 122.4, 121.5, 117.5, 116.5, 107.9, 99.8, 52.5, 34.7, 34.2, 30.3, 30.1, 30.0, 27.1, 26.2, 25.7, 25.6, 24.0, 20.9, 18.9, 18.6, 14.2, 1.4 ppm.

Example 10 6′-Cyano-5-(PDMS(855)-undecoyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine]

6′-Cyano-5-(PDMS(855)-undecoyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] was synthesised according to the procedure for the preparation of 9′-(PDMS(855)-undecoyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] (Example 5) using 6′-cyano-5-hydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] in place of 9′-hydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine], column chromatography (silica) 1:20, ethyl acetate:hexane (68%). ¹H NMR(C₂D₆O) δ=0.11 (bs), 0.60 (4H, m), 0.90 (3H, m), 1.24-1.51 (24H, m), 1.72 (2H, m), 2.56 (2H, t, J 7.31), 2.78 (1H, s), 6.65 (1H, d, J 9.5), 6.91 (1H, s), 6.94 (1H, s), 7.63-7.83 (3H, m), 8.04 (1H, s), 8.10 (1H, d, J 8.04), 8.71 (1H, d, J 8.04) ppm. ¹³C NMR(C₂D₆O) δ=172.8, 155.4, 145.9, 145.8, 144.0, 137.4, 131.5, 129.3, 127.7, 125.5, 124.4, 123.5, 121.7, 117.4, 116.6, 111.8, 108.2, 100.2, 71.7, 53.0, 34.7, 34.3, 30.3, 30.1, 30.1, 27.1, 26.2, 25.7, 25.6, 24.0, 20.9, 18.9, 18.6, 14.2, 1.5 ppm.

Example 11 5-Methoxy-9′-(PDMS(855)-undecoyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine]

5-Methoxy-9′-(PDMS(855)-undecoyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] was synthesised according to the procedure for the preparation of 9′-(PDMS(855)-undecoyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] (Example 5) using 5-methoxy-9′-hydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] in place of 9′-hydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine], column chromatography (silica) 1:20, ethyl acetate:hexane (75%). ¹H NMR(C₂D₆O) δ≠0.10 (bs), 0.59 (4H, m), 0.90 (3H, m), 1.24-1.55 (22 h, m), 1.79 (2H, m), 2.69 (3H, s), 2.80 (3H, s), 3.77 (1H, s), 6.57 (1H, d, J 8.77), 6.73 (1H, d, J 2.19), 6.81 (1H, d, J 2.19), 7.04 (1H, d, J 8.77), 7.18 (1H, dd, J 8.77, 2.19), 7.77-7.92 (3H, m), 8.22 (1H, d, J 2.19) ppm. ¹³C NMR (C₂D₆O) δ≠172.5, 155.5, 151.8, 151.0, 145.7, 142.6, 138.2, 132.7, 130.9, 130.2, 128.1, 123.8, 120.5, 117.2, 113.7, 112.7, 110.0, 108.4, 100.1, 56.1, 52.7, 34.8, 34.3, 30.4, 30.2, 30.2, 27.1, 26.3, 25.7, 24.1, 20.9, 19.0, 18.6, 14.2, 1.5 ppm.

Example 12 2-(9′-(PDMS(855)-undecoyl)oxy-ethyl ester)-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine]

2-(9′-(PDMS(855)-undecoyl)oxy-ethyl ester)-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] was synthesised according to the procedure for the preparation of 9′-(PDMS(855)-undecoyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] (Example 5) using 2-(9′-oxyethanol)-1,3,3,-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] in place of 9′-hydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine]. ¹H NMR(C₂D₆O) δ=0.10 (bs), 0.58 (4H, m), 0.89 (3H, m), 1.24-1.49 (22H, m), 1.78 (2H, m), 2.51 (2H, t, J 7.31), 2.68 (2H, t, J 7.31), 2.77 (3H, s), 6.65 (1H, d, J 7.68), 6.73 (1H, dd, J 1.96), 7.04 (1H, d, J 8.77), 7.10-7.24 (3H, m), 7.75-7.93 (3H, m), 8.23 (1H, d, J 2.56) ppm. ¹³C NMR(C₂D₆O) δ=170.3, 152.0, 151.0, 136.7, 132.6, 130.9, 130.2, 128.8, 128.1, 122.3, 120.7, 120.5, 117.2, 113.7, 108.0, 99.7, 52.5, 34.8, 34.2, 30.3, 30.2, 30.1, 29.9, 29.8, 28.7, 27.1, 26.2, 25.8, 25.7, 24.0, 21.0, 18.9, 18.6, 14.8, 14.2, 1.4 ppm.

Example 13 5-methyl carboxylate-6-(PDMS(855)-undecoyl)-2,2-bis(4-methoxyphenyl)-2H-napthol[1,2-b]pyran

A solution of the poly(dimethylsiloxane) monocarboxydecoyl chloride (0.78 g, 7.34×10⁻⁴ mol) in dichloromethane (5 mL) was slowly added to a solution of 5-methyl carboxylate-6-hydroxy-2,2-bis(4-dimethoxyphenyl)-2H-naptho[1,2-b]pyran (0.29 g, 6.2×10⁻⁴ mol) and triethylamine (0.12 g, 1.22 mmol) in dichloromethane (10 mL) The solution was stirred at room temperature under N₂ for 2 hour. Water (20 mL) was added and the solution was extracted, dichloromethane (3×20 mL), followed by removal of the solvent in vacuo then chromatography (silica, 5:1 hexane/ethyl acetate) to give a red viscous oil (0.89 g, 96%). ¹H NMR (C₂D₆O) δ=0.10 (bs), 0.59 (4H, m), 0.90 (3H, m), 1.34 (24H, m), 1.77 (2H, m), 2.74 (2H, t, J 7.68), 3.75 (6H, s), 3.93 (3H, s), 6.40 (1H, d, J 10.23), 6.95 (1H, d, J 8.77), 7.44 (4H, d, J 8.77), 7.53-7.72 (2H, m) 7.84 (1H, d, J 8.41), 8.41 (1H, d, J 7.68) ppm. ¹³C NMR (C₂D₆O) δ=172.2, 166.3, 160.1, 146.7, 140.3, 137.7, 130.2, 128.9, 128.7, 128.5, 128.3, 127.1, 123.5, 123.1, 121.7, 120.9, 114.3, 83.5, 55.5, 52.8, 34.3, 30.4, 30.2, 30.2, 27.1, 26.3, 25.6, 24.1, 19.0, 18.7, 14.3, 1.6, 1.5 ppm.

Example 14 5-Methyl carboxylate-6-(PDMS(855)-undecoyl)-2,2-(4-methoxyphenyl)-2H-napthol[1,2-b]pyran

5-Methyl carboxylate-6-(PDMS(855)-undecoyl)-2,2-(4-methoxyphenyl)-2H-napthol[1,2-b]pyran was synthesised according to the procedure for 5-methyl carboxylate-6-poly(dimethylsiloxane)-undecyl-2,2-bis(4-methoxyphenyl)-2H-napthol[1,2-b]pyran (Example 13) using 5-methyl carboxylate-6-hydroxy-2,2-(4-methoxyphenyl)-2H-naptho[1,2-b]pyran in place of 5-methyl carboxylate-6-hydroxy-2,2-bis(4-dimethoxyphenyl)-2H-naptho[1,2-b]pyran. ¹H NMR (C₂D₆O) δ=0.09 (bs), 0.58 (4H, m), 0.89 (4H, m), 1.35 (22H, m), 1.77 (2H, m), 2.75 (2H, t, J 7.31), 3.75 (3H, s), 3.93 (3H, s), 6.46 (1H, d, J 10.23), 6.88 (2H, d, J 8.77), 6.99 (1H, d, J 10.23), 7.21-7.42 (3H, m), 7.47 (2H, d, J 8.77), 7.51-7.74 (4H, m), 7.85 (1H, d, J 7.67), 8.45 (1H, d, J 7.67) ppm. ¹³C NMR (C₂D₆O) δ=172.2, 166.3, 160.2, 146.7, 145.9, 140.4, 137.4, 130.0, 129.1, 129.0, 128.8, 128.6, 128.4, 128.3, 127.4, 127.1, 123.5, 123.0, 121.9, 120.9, 114.4, 114.3, 83.6, 55.5, 52.8, 34.3, 30.4, 30.2, 30.2, 29.9, 27.1, 26.2, 25.5, 24.0, 18.9, 18.6, 14.2, 1.5 ppm.

Example 15 5-Methyl carboxylate-6-(PDMS(855)-undecoyl)-2,2-bis(4-dimethylaminophenyl)-2H-napthol[1,2-b]pyran

5-Methyl carboxylate-6-(PDMS(855)-undecoyl)-2,2-bis(4 dimethylaminophenyl)-2H-napthol[1,2-b]pyran was synthesised according to the procedure for 5-methyl carboxylate-6-poly(dimethylsiloxane)-undecyl-2,2-bis(4-methoxyphenyl)-2H-napthol[1,2-b]pyran (Example 13) using 5-methyl carboxylate-6-hydroxy-2,2-bis(4-dimethylaminophenyl)-2H-naptho[1,2-b]pyran in place of 5-methyl carboxylate-6-hydroxy-2,2-bis(4-dimethoxyphenyl)-2H-naptho[1,2-b]pyran. ¹H NMR (C₂D₆O) δ=0.10 (bs), 0.59 (4H, m), 0.89 (3H, m), 1.34 (24H, m), 1.77 (2H, m), 2.73 (2H, t, J 7.31), 2.89 (12H, s), 3.92 (3H, s), 6.33 (1H, d, J 10.05), 6.68 (4H, d, J 8.95), 6.89 (1H, d, J 10.05), 7.32 (4H, d, J 8.95), 7.50-7.69 (2H, m), 8.37 (1H, d, J 8.41) ppm. ¹³C NMR (C₂D₆O) δ=172.3, 166.5, 150.9, 147.1, 139.9, 133.4, 130.9, 128.5, 128.4, 128.3, 128.2, 127.1, 123.3, 123.1, 121.0, 120.9, 114.3, 112.6, 84.0, 52.8, 40.5, 34.3, 30.4, 30.2, 30.2, 29.9, 27.1, 26.2, 25.5, 24.0, 18.9, 18.6, 14.2, 1.5 ppm.

Example 16 5-(Carboxylic acid 2-(PDMS(855)-undecoyl)-oxy-ethyl ester)-9-(dimethylamino)-2,2-(4-dimethylaminophenyl)-2H-napthol[1,2-b]pyran

5-(Carboxylic acid 2-(PDMS(855)-undecoyl)-oxy-ethyl ester)-9-(dimethylamino)-2,2-(4-dimethylaminophenyl)-2H-napthol[1,2-b]pyran was synthesised according to the procedure for 5-methyl carboxylate-6-poly(dimethylsiloxane)-undecyl-2,2-bis(4-methoxyphenyl)-2H-napthol[1,2-b]pyran (Example 13) using 5-(carboxylic acid 2-hydroxy-ethylester)-9-(dimethylamino)-2,2-(4-dimethyl-aminophenyl)-2H-napthol[1,2-b]pyran in place of 5-methyl carboxylate-6-hydroxy-2,2-bis(4-dimethoxyphenyl)-2H-naptho[1,2-b]pyran. ¹H NMR (C₂D₆O) δ=0.11 (bs), 0.58 (4H, m), 0.88 (3H, m), 1.30 (24H, m), 1.61 (2H, m), 2.36 (2H m), 2.81 (6H, s), 2.87 (6H, s), 4.48 (2H, m), 4.54 (2H, m), 5.73 (1H, s), 6.20 (1H, dd, J 9.87, 2.92), 6.46-6.69 (2H, m), 7.02-7.48 (8H, m), 7.60 (1H, d, J 10.96), 7.74 (1H, d, J 10.23), 8.15 (1H, s) ppm.

Example 17 5-(Carboxylic acid 2-(PDMS(855)-undecoyl)-oxy-ethyl ester)-9-(dimethylamino)-2,2-bis(4-dimethylaminophenyl)-2H-napthol[1,2-b]pyran

5-(Carboxylic acid 2-(PDMS(855)-undecoyl)-oxy-ethyl ester)-9-(dimethylamino)-2,2-(4-dimethylaminophenyl)-2H-napthol[1,2-b]pyran was synthesised according to the procedure for 5-methyl carboxylate-6-poly(dimethylsiloxane)-undecyl-2,2-bis(4-methoxyphenyl)-2H-napthol[1,2-b]pyran (Example 13) using 5-(carboxylic acid 2-hydroxy-ethyl ester)-9-(dimethylamino)-2,2-bis(4-dimethylaminophenyl)-2H-napthol[1,2-b]pyran in place of 5-methyl carboxylate-6-hydroxy-2,2-bis(4-dimethoxyphenyl)-2H-naptho[1,2-b]pyran. ¹H NMR (C₂D₆O) δ=(C₂D₆O) 0.12 (bs), 0.58 (4H, m), 0.91 (3H, m), 1.31 (24H, m), 1.62 (2H, m), 2.35 (2H m), 2.88 (12H, s), 3.13 (6H, s), 3.92 (3H, s), 4.40-4.59 (4H, m), 6.28 (1H, d, J 10.05), 6.66 (4H, d, J 8.95), 7.23 (1H, dd, J 9.14, 2.56), 7.36 (5H, d, J 10.05), 7.72 (1H, d, J 9.14), 7.90 (1H, s). ¹³C NMR(C₂D₆O) δ=173.6, 167.4, 151.1, 150.7, 148.1, 134.1, 130.9, 129.9, 129.8, 128.4, 126.1, 125.7, 122.5, 120.2, 117.4, 116.4, 112.6, 100.4, 82.8, 63.2, 62.7, 41.8, 40.5, 34.6, 34.3, 30.4, 30.2, 27.1, 26.2, 25.8, 24.0, 18.9, 18.6, 14.2, 1.4 ppm.

Example 18 9′-(PDMS(1077)propyl-ethoxy-succinyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]naphtha[2,1-b][1,4]oxazine]

9′-(Monocarboxy-succinyl)-1,3,3-trimethylspiro[indoline-2,3′-[3h]naphtha [2,1-b][1,4]oxazine as prepared in Example 6 (0.6 g 1.35 mmoles) was dissolved in dichloromethane, then monocarbinol terminated polydimethylsiloxane (MCR-C12 from ABCR) (1.76 g, 1.1 equivalents, FW ca 1180) and dimethylaminopyridine (0.135 mmoles 0.1me, 16 mg) were added. Then dicyclohexylcarbodiimide (0.306 g, 1.1 equiv, 1.485 mmoles) in dichloromethane was added dropwise. The reaction was allowed to stir at room temperature. Tlc analysis indicated a rapid reaction with no starting spirooxazine observed after 1 hour. The reaction was filtered and evaporated then chromatographed on silica with hexane:ether (1:1) to give 1.3 g of clear bluish green oil. ¹H NMR (acetone-d₆) δ=0.09 (s, Si-Me), 0.5 (mult., 2H, alkyl) 1.62 (mult., Indole methyls and oligomer CH₂—Si), 1.4-1.8 (mult, alkyl oligomer), 2.77 (s, 3H, 8-H), 2.82 (mult. succinic CH₂), 3.00 (mult, succinic CH₂), 3.44 (t, J=7.2, 2H), 3.65 (apparent t, J=ca. 5, 2H), 4.25 (apparent t, J=ca. 5, 2H), 6.65 (d, J=7.8, 7-H), 6.87 (t, J=7.3, 5-H), 7.04 (d, J=8.5, 5′-H), 7.14 (d, J=7.3, 4-H), 7.22 (apparent t, 2H, 6 & 8′-H), 7.81 (d, J=9.3, 6′-H), 7.82 (s, 2′H), 7.88 (d, J=8.6, 7′-H), 8.25 (d, J=2.3, 10′-H) ppm.

Example 19 5,9′-Di(PDMS(855)-undecoyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]naphtha[2,1-b][1,4]oxazine]

This was made in the same manner as described for Example 3 except poly(dimethylsiloxane) monocarboxydecyl chloride was used in place of succinic acid chloride mono-PEG(350). After addition of poly(dimethylsiloxane) monocarboxydecyl chloride (synthesised in Example 4) to a dichloromethane solution of 5,9-dihydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]naphtha[2,1-b][1,4]oxazine with triethyl amine the reaction was let stir for about 1 hour. The reaction was worked up by washing with water and brine. The dichloromethane was evaporated to give 2.5 g of crude product. This was purified by column chromatography (silca, ether:hexane 2:1) to give 1.4 g of brown oil. ¹H NMR (acetone-d₆) δ=0.13 (s, Si-methyl), 0.6 (mult., alkyl), 0.90 (mult., alkyl), 1.3-1.4 (mult, gem dimethyl groups+other aliphatic) 2.1-2.4 (mult, alkyl), 2.7 (s, 3H, N—CH₃), 6.5-7.5 (mult, aromatic), 7.5-8.2 (mult, aromatic). Photochromic dye signals are very small due to the relatively large amount of PDMS. The methyl groups on the dye provide the clearest signals.

Example 20 PDMS (855)-undecoyl 2-(4-phenylazo-phenoxy)ester

4-Phenylazophenol (0.127 g, 0.6 mmoles) was dissolved in ether (5-10 mL) and triethylamine (0.1 mL) was added. Then a solution of poly(dimethylsiloxane) monocarboxydecoyl chloride terminated (prepared as Example 4) (0.73 g) dissolved in dichloromethane was added dropwise at room temperature. The reaction was stirred at room temperature for two hours and monitored by tlc (ether). The reaction was worked up by dilution with ether and washing with water and then brine. The organic layer was evaporated and chromatographed on silica with ether to give an orange oil (200 mg).

Example 21 9′-(Stearoyl)-1,3,3-trimethylspiro[indoline-2,3′-[3h]naphtha[2,1-b][1,4]oxazine

9′-Hydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]naphtha[2,1-b][1,4]oxazine] (0.405 g, 1.2 mmoles) and triethylamine (0.32 mL, 234 mg, 2.32 mmoles) were added together in dichloromethane (20 mL) and stearoyl chloride (456 mg, 1.5 mmol) in dichloromethane was added dropwise to the solution at room temperature under argon protection. The reaction was stirred for one hour and tlc showed reaction had completed. The reaction was worked up by washing with water, drying (MgSO₄) and evaporation to give 450 mg of crude product. The sample was recrystallized from 80-100° C. petroleum ether to give 300 mg (42%) of white solid. ¹H NMR (methylene chloride-d₂) δ 0.88 (t, 3H, ‘c’-H), 1.28 (s, —CH₂—), 1.34 (s, methyl), 1.78 (mult., 2H, ‘b’), 2.61 (t, J=7.3, ‘a’), 2.74 (s, 3H, N-methyl), 6.57 (d, J=7.7, 7-H), 6.92 (t, J=7.4, 5-H), 7.03 (d, J=8.1, 5′-H), 7.09 (d, 4-H), 7.10 (dd, J=8.8 & 2.1, 8′-H), 7.20 (t of d, J=7.7 & 1.3, 6-H), 7.69 (d, J=8.8, 6′-H), 7.74 (s, 2′-H), 7.77 (d, J=9.0, 7′-H), 8.23 (d, J=2.1, 10′-H) ppm. MS (EI): m/z 610.4 (M⁺, 60%) 595.4 (15), 329 (20), 185 (10), 159.1 (100), 144.1 (15). MS (HR) m/z 610.4134 (C₄₀H₅₄N₂O₃ requires 610.4134).

Example 22 9′-(2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-Heneicosafluoro-1-undecyl-succinyl)-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine]

Step 1

5 g (9 mmol) of 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heneicosafluoro-1-undecanol, 0.91 g of triethyl amine, 0.90 g succinic anhydride, 50 mg methanol and 25 mg DMAP were added to 60 mL diethyl ether/dichloromethane(6:1). The reaction was stirred overnight at 40° C. Then the product was washed with 0.5 M HCl, water and then brine and dried with MgSO₄. 3.9 g of a pink solid-66% yield.

Step 2

4 g of fluorinated succinic acid prepared in step 1 was added to 70 mL diethyl ether/dichloromethane solution (6:1). Then 1.83 g of thionyl chloride was added dropwise. The reaction was left to stir over forty eight hours and then refluxed for four hours. The final product was rotary evaporated to remove the thionyl chloride to give 3.8 g of yellow solid.

Step 3

1.5 g of 9′-Hydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] and 0.66 g triethylamine were added to 90 mL diethyl ether/dichloromethane solution (5:1). Then 3.5 g of fluorinated acid chloride in 10 mL diethyl ether was added, dropwise under argon. The reaction was refluxed for three hours. Completion of the reaction was confirmed by tlc (3:1 ether, hexane). The reaction was washed with water, brine and MgSO₄ and then rotary evaporated. The final product was purified using column chromatography (3:1 ether, hexane). 1.9 g of yellow powder was obtained. ¹H NMR (acetone-d₆) δ=1.33 & 1.35 (s, 6H, gem dimethyls), 2.77 (s, 3H, N-methyl), 2.85 & 3.05 (mults, 4H, succinic hydrogens), 4.90 (t, J=14.3, 2H, CH₂CF₂), 6.65 (d, J=7.7, 1H, 7-H), 6.86 (t of d, J=7.4, J=0.7, 1H, 5-H), 7.04 (d, J=9.0, 5′-H), 7.1-7.72 (mult, 3H, 4-H, 8′-H, 6-H), 7.80 (d, J=9.0, 6′-H), 7.82 (s, 1H, 2′-H), 7.88 (d, J=ca 8.7, 1H, 7′-H), 8.25 (d, J=1.8, 10′-H) ppm.

Comparative Example CE1 9′-Propionate-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine]

A magnetically stirred solution of 9′-hydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] (91.0 g, 2.91 mmol) in dichlormethane (50 mL) was treated with triethylamine (0.84 mL, 0.61 g, 6.03 mmol) followed, dropwise, by a solution of propionyl chloride (0.54 mL, 0.58 g, 6.27 mmol) in dichlormethane (20 mL). The resulting solution was stirred under N₂ at room temperature for 30 minutes. Water (100 mL) was added and the solution extracted with dichloromethane (3×50 mL). Removal of the solvent in vacuo followed by flash chromatography (silica gel, 1:5 (ethyl acetate:hexane)) gave the title compound as a green solid (1.11 g, 95%). ¹H NMR (CDCl₃) δ 1.32 (3H, t, J=7.31), 1.35 (6H, s), 2.57 (2H, q, J=7.31), 2.76 (3H, s), 6.58 (d, J=7.7, 1H, 7-H), 6.91 (t, J=7.3, 1H, 5-H), 6.99 (d, J=8.8, 5′-H), 7.09 (d, J=7.3, 1H, 4-H), 7.13 (d of d, J=8.0 & 2.2, 1H, 8′-H), 7.21 (t of d, J=7.7 & 1.5, 1H, 6-H), 7.66 (d, J=8.7, 6′-H), 7.75 (s, 1H, 2′-H), 7.73 (d, J=8.7, 1H, 7′-H), 8.23 (d, J=2.6, 10′-H) ppm.

Comparative Example CE2 5-Propionate-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine]

5-Propionate-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] was synthesised according to the procedure for the preparation of 9′-propionate-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] (CE1) using 5-hydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] in place of 9′-hydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] (51%). ¹H NMR (C₂D₆O) δ=1.19 (3H, t, J 7.31), 1.33 (3H, s), 1.38 (3H, s), 2.57 (2H, q, J 7.31), 2.76 (3H, s), 6.64 (1H, d, J 8.77), 6.91 (1H, dd, J 7.31, 2.19), 6.93 (1H, s), 7.08 (1H, d, J 8.77), 7.42 (1H, dd, J 8.41, 1.46), 7.59 (1H, dd, J 8.41, 1.46), 7.75-7.88 (3H, m), 8.57 (1H, d J 8.41) ppm. ¹³C NMR (C₂D₆O) δ=173.6, 151.6, 146.1, 145.6, 144.9, 137.8, 131.8, 131.2, 130.4, 128.7, 127.9, 125.0, 123.9, 122.3, 121.5, 117.5, 116.6, 108.0, 99.8, 52.5, 30.0, 27.9, 25.6, 20.8, 9.4 ppm.

Comparative Example CE3 6′-Cyano-5-propionate-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine]

6′-cyano-5-propionate-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] was synthesised according to the procedure for the preparation of 9′-propionate-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] (CE1) using 6′-cyano-5-hydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] in place of 9′-hydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] (51%). ¹H NMR (C₂D₆O) δ=1.19 (3H, t, J 7.31), 1.34 (3H, s), 1.39 (3H, s), 2.58 (2H, q, J 7.31), 2.78 (3H, s), 6.66 (1H, d, J 8.95), 6.91 (1H, dd, J 7.31, 2.19), 6.95 (1H, s), 7.60-7.82 (3H, m), 8.05 (1H, s), 8.09 (1H, d, J 7.68), 8.70 (1H, d J 7.68) ppm. ¹³C NMR(C₂D₆O) δ=173.6, 155.5, 145.9, 144.0, 137.5, 131.5, 129.4, 129.3, 127.7, 127.6, 127.6, 125.5, 124.4, 123.4, 121.7, 117.4, 116.6, 111.7, 108.2, 100.3, 53.0, 30.0, 27.9, 25.6, 20.8, 9.4 ppm.

Comparative Example CE4 5-Methoxy-9′-propionate-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine]

5-Methoxy-9′-propionate-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] was synthesised according to the procedure for the preparation of 9′-propionate-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] (CE1) using 5-methoxy-9′-hydroxy-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] in place of 9′-hydroxy-1,3,3-trimethylspiro [indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] (62%). ¹H NMR(C₂D₆O) δ=1.24 (3H, t, J 7.68), 1.30 (6H, bs), 2.69 (2H, q, J 7.68), 3.80 (3H, s), 6.72-6.93 (3H, m), 7.05 (1H, d, J 9.14), 7.19 (1H, dd, J 8.77, 2.19), 7.78 (1H, s), 7.79 (1H, d, J 7.68), 8.24 (1H, d, J 2.56) ppm. ¹³C NMR (C₂D₆O) δ=173.4, 152.2, 151.0, 146.6, 145.7, 138.4, 136.0, 132.7, 131.0, 130.2, 128.1, 123.5, 121.9, 120.5, 117.2, 115.3, 113.7, 113.2, 100.4, 56.4, 52.6, 32.7, 28.1, 25.8, 20.9, 9.4 ppm.

Comparative example CE5 2-(9′-Oropionic acid oxy-ethyl ester)-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine]

2-(9′-Propionic acid oxy-ethyl ester)-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] was synthesised according to the procedure for the preparation of 9′-propionate-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] (CE1) using 2-(9′-oxyethanol)-1,3,3-trimethylspiro[indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine] in place of 9′-hydroxy-1,3,3-trimethylspiro [indoline-2,3′-[3H]napth[2,1-b][1,4]oxazine]. ¹H NMR (C₂D₆O) δ=1.11 (3H, t, J 7.68), 1.33 (3H, s), 1.35 (3H, s), 2.38 (2H, q, J 7.50), 2.77 (3H, s), 4.42 (2H, t, J 4.08), 4.51 (2H, t, J 4.08), 6.65 (1H, d, J 7.68), 6.83-6.93 (2H, m), 7.08 (1H, d, 8.97), 7.11-7.23 (2H, m), 7.70 (1H, d, J 8.78), 7.76 (1H, d, J 8.78), 7.80 (1H, s), 7.95 (1H, d, J 1.83) ppm.

Comparative Example CE6 5-Methyl carboxylate-6-propionic acid ester-2,2-bis(4-methoxyphenyl)-2H-naptho[1,2-b]pyran

A mechanically stirred solution of 5-methyl carboxylate-6-hydroxy-2,2-bis(4-dimethoxyphenyl)-2H-naptho[1,2-b]pyran (0.50 g, 1.07 mmol) and triethylamine (0.24 g, 2.35 mmol) in dichloromethane (10 mL) was treated dropwise with a solution of propionyl chloride (0.19 g, 2.02 mmol) in dichloromethane (10 mL). The resulting solution was stirred at room temperature under N₂ for 30 minutes. Water (50 mL) was added and the solution was extracted with dichloromethane (3×50 mL). Removal of the solvent in vacuo followed by column chromatography (silica, eluent hexane/ethyl acetate 3/1) gave the title compound as an red solid (0.51 g, 91%). ¹H NMR (C₂D₆O) δ=1.26 (3H, t, J 7.68), 2.76 (2H, q, J 7.68), 3.72 (6H, s) 3.94 (3H, s), 6.39 (1H, d, J 10.05), 6.88 (2H, d, J 8.77), 6.99 (1H, d, J 10.05, 7.45 (1H, d, J 8.77), 7.51-7.71 (2H, m), 7.88 (1H, d, J 8.41), 8.42 (1H, d, J 7.86) ppm. ¹³C NMR(C₂D₆O) δ=173.1, 166.4, 160.1, 146.7, 140.4, 137.7, 130.3, 128.9, 128.8, 128.6, 128.3, 127.1, 123.5, 123.0, 121.6, 120.8, 114.4, 83.5, 55.5, 52.9, 27.8, 9.4 ppm.

Comparative Example CE7 5-Methyl carboxylate-6-propionic acid ester-2,2-(4-methoxyphenyl)-2H-naptho[1,2-b]pyran

5-methyl carboxylate-6-propionic acid ester-2,2-(4-dimethoxyphenyl)-2H-naptho[1,2-b]pyran was synthesised according to the procedure for 5-methyl carboxylate-6-propionic acid ester-2,2-bis(4-dimethoxyphenyl)-2H-naptho[1,2-b]pyran (CE6) using 5-methyl carboxylate-6-hydroxy-2,2-(4-dimethoxyphenyl)-2H-naptho[1,2-b]pyran in place of 5-methyl carboxylate-6-hydroxy-2,2-bis(4-dimethoxyphenyl)-2H-naptho[1,2-b]pyran. This provided an orange solid (79%). ¹H NMR (C₂D₆O) δ=1.29 (3H, t, J 7.49), 2.78 (2H, q, J 7.49), 3.68 (3H, s), 3.95 (3H, s), 6.46 (1H, d, J 10.05), 6.88 (2H, d, J 8.77), 7.07 (1H, d, J 10.05), 7.20-7.44 (3H, m), 7.51 (2H, d, J 8.77), 7.55-7.71 (4H, m), 7.91 (1H, d, J 8.56), 8.50 (1H, d, J 8.77) ppm. ¹³C NMR (C₂D₆O) δ=173.2, 166.4, 160.2, 146.8, 146.0, 140.6, 137.4, 130.1, 129.2, 129.1, 129.0, 128.7, 128.5, 128.4, 127.5, 127.2, 123.6, 123.1, 122.0, 120.8, 114.5, 114.4, 83.7, 55.6, 53.0, 27.9, 9.6 ppm.

Comparative Example CE8 5-(Carboxylic acid 2-methyl ester)-9-(piperidino)-2,2-(4-dimethylaminophenyl)-2H-napthol[1,2-b]pyran

James Robinson Midnight Grey was used as supplied. NMR and mass spectral analysis suggested a structure given above. The structure above is the best fit with the spectral data and the information in U.S. Pat. No. 6,387,512.

Comparative Example CE9 5-Methyl carboxylate-6-propionic acid ester-2,2-bis(4-dimethylaminophenyl)-2H-naptho[1,2-b]pyran

5-Methyl carboxylate-6-propionic acid ester-2,2-bis(4-dimethylaminophenyl)-2H-naptho[1,2-b]pyran was synthesised according to the procedure for 5-methyl carboxylate-6-propionic acid ester-2,2-bis(4-dimethoxyphenyl)-2H-naptho[1,2-b]pyran (CE6) using 5-methyl carboxylate-6-hydroxy-2,2-bis(4-dimethylaminophenyl)-2H-naptho[1,2-b]pyran in place of 5-methyl carboxylate-6-hydroxy-2,2-bis(4-dimethoxyphenyl)-2H-naptho[1,2-b]pyran. This provided a pale blue solid (85%). ¹H NMR(C₂D₆O) δ=1.25 (3H, t, J 7.49), 2.75 (2H, q, J 7.49), 2.88 (12H, s), 3.92 (3H, s), 6.33 (1H, d, J 10.05), 6.67 (4H, d, J 6.67), 6.90 (1H, d, J 9.89), 7.33 (4H, d, J 8.95), 7.50-7.68 (2H, m), 7.83 (1H, d, J 7.68), 8.38 (1H, d, J 7.68) ppm. ¹³C NMR (C₂D₆O) δ=173.1, 166.5, 150.9, 150.9, 147.1, 139.9, 136.0, 133.4, 131.0, 128.5, 128.4, 128.2, 127.1, 123.4, 123.1, 120.9, 114.3, 112.6, 84.0, 52.8, 40.5, 27.7, 9.4 ppm.

Comparative Example CE10 Propionic acid 4-phenylazo-phenyl ester

4-Phenylazophenol (0.25 g, 1.26 mmoles) was dissolved in ether (5-10 mL) and triethylamine (0.26 mL) was added. Then propanoyl chloride (0.14 g 1.5 mmoles) in ether (1 mL) was added dropwise at room temperature. The mixture was stirred and reaction was rapidly completed. The reaction mixture was washed with water, dilute acid and brine and dried with magnesium sulfate. The solvent was evaporated to give 0.23 g (72%) of product. ¹H NMR (CDCl₃) δ=1.16 (3H, t, J=7.7), 2.40 (2H, q J=7.7), 7.25 (2H, m), 7.40-7.58 (3H, m), 7.88-8.0 (4H, m) ppm.

Example 23 NMR Experimental Observation of Nanoencapsulation

The two dyes described in Example 1 and Example 5 were examined by ¹H NMR spectroscopy to determine whether the attached oligomer was interacting with the photochromic dye in a manner that was consistent with nanosolvation/nanoencapsuation. This was carried out by dissolving the dye in deutero acetone and irradiating the dye with UV light. ROE (Rotational Overhausen Enhancement) experiment were performed while the dye was in the coloured state. ROE is a technique similar to NOE (Nuclear Overhausen Enhancement) but is modified for use in large molecules. The technique allows the through space proximity of hydrogens to be determined. Selected hydrogens are irradiated (with radio frequency) and other hydrogens are observed to see if they are enhanced. If another hydrogen is close enough, then energy is transferred to it from the irradiated hydrogen.

It was found that PEG oligomer of Example 1 does coil near or around the dye. This is shown in the ROE experiment (see top spectrum of FIG. 5) where energy irradiated into the first CH₂ group of the first PEG unit was transferred to the marked hydrogens on the other side of the molecule. This transfer is evidenced by an enhancement of the signals due to those hydrogens. For this to happen those hydrogens must be in close proximity to the hydrogen being irradiated. Thus the PEG is coiling near or around the dye rather than being lost into the solvent. In the clear form there is a weaker association. Thus when in a lens environment it can be expected that the PEG chains will similarly coil near/around the dye molecule and so provide a favourable switching environment. The bottom two spectra of FIG. 5 are conventional spectra of the molecule in solution obtained by subtraction and normally.

Similarly for the dyes of Example 5 with the PDMS oligomer it was shown that the oligomer coils around the molecule. (FIGS. 6 and 7) In the ROE experiment, energy transfer was observed between the mid methylenes and end group of the PDMS chain with the central H of the coloured form of the spirooxazine (FIG. 6). Energy transfer was also observed between the mid methylenes of the undecyl portion of the oligomer and the 4 hydrogen on the indole (FIG. 7). Thus the PDMS chain must be highly localised around the spirooxazine. There is a similar but weaker association in the clear form.

These experiment show that the oligomers are not only localised around the dye molecule but wrap around the dye to varying degrees with interactions between the oligomer and the far side of the dye observed, and in the case of the PDMS oligomer there are multiple sites of interaction. This nanoencapsulation would be expected to be greater in the rigid environment of a polymer matrix where the mobility of the surrounding host medium (in this case the host polymer) is much less.

Example 24 Photochromic Behaviour of Dyes Cast in a Cure Polymer Matrix

Table 6 gives the fade speed results for the example dyes that were cast in to test lenses directly.

The following is a standard formulation and testing procedure which we used to assess the performance of many photochromic compounds of the invention. The test is referred to in the specification and claims as “the standard photochromic cast test”.

The monomer mix consisted of 16 g of 2,2′-bis[4-methacryloxyethoxy)phenyl]propane known as Nouryset 110, 4 g of polyethylenglycol 400 dimethacrylate known as NK ester 9G and 80 mg (0.4%) of AIBN. This is referred to though out as the “monomer mix A”. The dye was mixed into the monomer then placed into small moulds. The moulds consisted of a small silicon or viton o-ring (14.5 mm internal diameter, width 2.6 mm). This was stuck to a microscope slide using cyanoacrylate glue. The monomer mix was poured into the mould and another microscope slide was placed on top and air bubbles were excluded. The two plates were clipped together and the sample heated at 75° C. for 16 hours. The lens was recovered and was typically 14.2 mm in diameter and 2.6 mm thick and weighed about 0.5 g.

All measurements were performed on a custom built optical bench similar to that described for the thin film observations in Example 8. The bench consisted of Cary 50 Bio UV-visible spectrophotometer fitted with a Cary peltier accessory for temperature control, a 280 W Thermo-Oriel xenon arc lamp, an electronic shutter, a water filter acting as a heat sink for the arc lamp, a Schott WG-320 cut-off filter and a Hoya U340 band-pass filter. The solution samples were placed in quartz cuvettes and solid samples were placed at 45 degree angle to both UV lamp and light path of spectrophotometer. The resulting power of UV light at the sample was measured using an Ophir Optronics Model AN/2 power meter giving 25 mW/cm².

The change in absorbance was measured by placing the appropriate sample in the bleached state and adjusting spectrophotometer to zero absorbance. The samples were then irradiated with UV light from the xenon lamp by opening the shutter and measuring the change in absorption. The absorption spectra were recorded for both the bleached and activated (coloured) state. The wavelength of the maxima in absorbance was then recorded and used for the monitoring of kinetics of activation and fade. Test lens samples were activated with 1000 seconds UV exposure. TABLE 6 Photochromic behaviour of dyes cast into a cured polymer matrix of monomer mix A consisting of 4:1 2,2′-bis[4- (methacryloxyethoxy)phenyl]propane and poly(ethylglycol (400) dimethacrylate. Example Dye Monomer T_(1/2) T_(3/4) Number (mg) (g) A_(o) (seconds) (seconds)  2 7.0 2.0152 1.61 9 50 CE 1 1.1 1.017 1.64 14 191  5 3.7 1.008 1.63 3 7 CE 1 1.1 1.017 1.64 14 191  6 4.0 1.0293 2.1 13 92 CE 1 1.1 1.017 1.64 14 191  9 3.9 1.009 1.13 3 12 CE 2 1.0 1.021 1.07 34 633 10 0.16 2.064 0.58 50 144 CE 3 0.176 1.871 1.85 128 721 11 5.3 1.56 2.35 13 29 CE 4 2.1 1.996 2.16 21 167 12 1.3 2.1610 1.19 8 36 CE 5 1.02 1.009 1.73 20 219 13 0.49 1.534 0.84 34 790 CE 6 0.52 1.517 1.93 78 3943 14 0.47 1.637 0.75 95 n/a CE 7 0.4 1.6914 2.15 212 7287 15 0.3 2.553 0.83 5 26 CE 9 0.74 2.012 1.10 247 2995 16 1.2 1.228 1.34 18 758 CE 8 0.59 1.853 1.11 185 1691 17 3.07 1.604 1.03 7.5 94 18 2.65 1.2964 1.98 8 36 CE 1 1.1 1.017 1.64 14 191 19 2.4 1.0072 0.85 15 84 20 1.92 1.030 0.26 2000 n/a CE 10 1.39 1.3392 0.5 >70000 n/a 21 1.22 1.257 1.67 32 441 CE 1 1.1 1.017 1.64 14 191 22 3.9 1.2912 1.80 9 43 CE 1 1.1 1.017 1.64 14 191

It can be seen in all examples that the presence of a polydimethylsiloxane oligomer, polyethylgylcol oligomer or perfluorinated alkane oligomer gave significantly faster fade speed as measured by T_(1/2) or T_(3/4). T_(1/2) is the time taken for the optical density to reduce by half from the initial maximum optical density of the coloured from when UV irradiation is stopped. T_(3/4) is time taken for the optical density to reduce by three quarters from the initial maximum optical density of the coloured form of the dye. In all those cases except for Example 6 (and Example 21), the reduction in T_(1/2) ranges from 40% to 95% and T_(3/4) by 60% to 99% as compared to the electronically identical comparison examples that do not have the oligomer. The following points are illustrated by these examples:

-   1. It is extremely surprising and unexpected to find that the     addition of a relatively large substituent such as a PDMS oligomer     (ca 1000 g mwt) would cause the dyes to switch faster than the     correspondingly electronically identical dye with only a propylate     substituent (29 g mwt) in a rigid polymer matrix. [Note that this     matrix is not tuned to encourage photochromic performance. This     tuning is typically done by addition of other monomers that ‘soften’     the entire matrix and so compromise physical properties of the lens     to some extent.] Example 5 is typical. Note the rapid colouration     and overshoot of example 5 as compared to CE1. (FIGS. 8 and 9). The     dyes are electronically identical yet the dye with the oligomer     (Example 5) not only fades faster but does so by a large margin with     the T_(1/2) and T_(3/4) reduced by 79% and 96% respectively as     compared to the comparison dye (CE1) in the identical matrix. -   2. The position of attachment of the oligomer makes no substantial     difference to the dyes performance. They are all much faster than     their corresponding comparison dyes. (See kinetic data for Examples     5, 9, 13, and 16 and corresponding comparative examples). -   3. The nature of the linking group between the oligomer and dye has     no apparent effect on the fade speed. They are all much faster than     their comparison dyes See kinetic data for example 5, 12 and 18 and     corresponding comparative examples. -   4. The nature of the linear of PDMS oligomer has little effect on     the fade performance with examples 5 and 18 with them significantly     out performing CE1 although the PDMS oligomers and linking groups     are different. -   5. Example 6 with the POSS substituent is different among the PDMS     dyes. The POSS group is relatively rigid (i.e. high Tg) as compared     to linear PDMS oligomers. Example 6 was a solid where as the dyes     with linear PDMS oligomers are oils or low melting point solids. Its     T_(1/2) is much the same as the comparison dye but its T_(3/4) is     significantly faster. This is likely to be due to the free volume     that the large POSS group would create around it. It is thought that     it is because of this free volume that the solid state crystalline     photochromism observed in Example 6 occurs. -   6. The concept of low Tg oligomers improving switching speed and     fade speed in particular is applicable for any photochromic dye that     involves a structural molecular rearrangement with spiro-oxazines     (Examples 2, 5, 6, 9, 10, 11, 12, 18, 23), chromenes (13, 14, 15,     16, 17) (FIGS. 10 and 11) and the azo (Example 20) (FIGS. 12 and 13)     dyes all shown to have a fade speed enhancement in their thermal     reverse reactions to the coloured state. Thus this is a generic     “bolt-on” solution for fade speed enhancement than does not alter     the colour of the dye. -   7. The addition of a high Tg oligomer such as stearyl (Example 21)     gave slower fade speeds. This further illustrates the need for low     Tg oligomers for fast fade speed and high Tg oligomer for slow fade     speed. -   8. The Tg of the oligomer is maybe more important than its     compatibility but compatibility still contributes to fade speed.     Example 2 which possess a long PEG chain of ca 16 units would be     expected to have some compatibility with the monomer mix A which     contains poly(ethyleneglycol) dimethacrylate. However fast fade is     still observed although not as fast as the PDMS example 5 (FIGS. 8     and 9). -   9. The kinetic results of examples as a whole, illustrate the     control over photochromic performance that can be obtained without     altering the electronic nature of the dye. This is very important as     it means no change in the colour occurs yet its fade speed can be     greatly changed. Note the three fade speed obtained for the     electronically identical dyes Example 5, CE1 and Example 21. T_(1/2)     ranges from 3 second to 32 seconds (one order of magnitude) and     T_(3/4) ranges from 7 second to 441 seconds (one and half orders of     magnitude). -   10. The electronic nature of the dye not only affects the observed     colour of the open form but can affect the switching speed. The     oligomer can not change that part of the switching speed of the dye     that is due to the electronic nature of the dye. For example,     Example 10 is an inherently slow switching dye even in solution. The     low Tg oligomer (ie PDMS) simply provides a near-solution like     environment to allow the due to switch as fast as it can. Example 9     switches much faster than Example 10. That is due to the different     electronic nature of the two dyes. But Example 10 still switches     much faster than the electronically identical comparison dye CE3 and     that is the effect of the low Tg nanoenvironment of the PDMS     oligomer.     Importance of the Attachment of the Oligomer.

It was shown that the oligomer must be attached to the dye for the fast fade effect to occur. Example 5 and CE1 were cast into separate lenses as before. A third test lens containing 1.18 mg CE5 and 1.44 mg of 10 cst PDMS in 1.1321 g of monomer mix A was also prepared. This lens was slightly hazy. It was clearly shown that the dye with the oligomer attached (Ex. 5) showed fast coloration and fade where as both the CE5 and the CE5+PDMS lens showed essentially the same slow kinetics (FIGS. 14 and 15). This also illustrates the great efficiency of the methodology of the attachment of the low Tg oligomer to the dye. Because the dye cannot be separated from its highly localised low Tg environment, very little is needed in the lens. As only small amounts of dye are needed to obtain the photochromic effect logically only a small amount of oligomer are added the formulation. However in order to get improved fade speed with conventional dyes comparatively very large amounts of “soft” monomer need to be added to the bulk host matrix. Thus the bulk mechanical properties of the lens are degraded.

Comparison Between Photochomic Dyes and a Commercial Photochromic Lens.

The improved kinetic performance of these modified photochromic dyes as compared to the state of the art is illustrated in the 16. Example 9 was cast in the monomer mix A (4:1 Nouryset 110:NK ester 9G) and compared to the premium fast fade photochromic lens “Sepctralite Velocity Transtions™”. The improvement in performance of the photochromic-PDMS conjugate over the current commercial lens is clear. Example 9 gave near-square wave performance that matched the light on light off cycles and returned to near 0.0 absorbance each cycle. The commercial lens gave a saw tooth response and returned to 0.4 absorbance (ca. 40% transmission) before each next light-on cycle. It must be noted that the host matrix containing example 9 is not optimised for photochromic response where as the commercial lens is. The compounds of this invention represents a significant and large advance on existing technology.

Example 25

The imbibition experiment was carried out by contacting the lens sample to the dye of Example 1 and paraffin oil mixture for three hours at 130° C. The lens was then cleaned with acetone when the lens was cooled to room temperature. The lens was photochromic when sufficient dye diffused into the lens.

Example 26 Fatigue Resistance Test

The fatigue test was carried out by exposing the lens (made from monomer mix A and the appropriate dye example) sample to an accelerated weathering condition then evaluating the change of lens colour before and after the fatigue. The weathering condition is equivalent to two years actual wearing of the lens in everyday life. The lens samples indoor colour shift and intensity change as well as the activated colour shift and intensity change are used to rate the sample fatigue property. It was shown that the PDMS chain did not significantly degrade photochromic dye fatigue resistance in a ophthalmic lens formulation by comparing results obtained from Example 13 and Comparative Example 6. 

1.-25. (canceled)
 26. A photochromic compound which is an adduct comprising a photochromic moiety and at least one pendent oligomer comprising a polysiloxane group.
 27. A photochromic compound comprising a photochromic moiety and at least one pendant oligomer group selected from the group consisting of polyether oligomers, polyalkylene oligomers, polyfluoroalkylene oligomers, poly(perfluoroalkylene glycol) oligomers, polydi(C₁ to C₁₀ hydrocarbyl)siloxane oligomers and mixtures thereof wherein the combined number of polydi(C₁ to C₁₀ hydrocarbyl)monomer units in the oligomers is at least
 5. 28. A photochromic compound according to claim 27 having the formula I: (PC)-(L(R)_(n))_(m)  I wherein PC is a photochromic moiety L is a bond or linking group; R is an oligomer chain; n is an integer from 1 to 3; m is an integer from 1 to 3; and wherein the total number of polydi(C₁ to C₁₀)siloxane monomer units in the oligomer R is at least
 5. 29. A photochromic compound according to claim 28 wherein the linking group L and oligomer R provide a longest chain length of at least 12 atoms.
 30. A photochromic compound according to claim 28 wherein the longest chain length is at least 15 atoms.
 31. A compound according to claim 28 wherein the photochromic moiety (PC) is selected from the group consisting of chromenes, spiropyrans; spiro-oxazines, fulgides, fulgimides, anils, perimidinespirocyclohexadienones, stilbenes, thioindigoids, azo dyes and diarylethenes.
 32. A photochromic compound according to claim 29 wherein the photochromic moiety (PC) is selected from the group consisting of naphthopyrans, benzopyrans, indenonaphthopyrans, phenanthropyrans, spiro(benzindoline) naphthopyrans, spiro(indoline)benzopyrans, spiro(indoline) naphthopyrans, spiroquinopyrans, spiro(indoline)pyrans, spiro(indoline)-naphthoxazines, spiro(indoline)pyridobenzoxazines, spiro(benzindoline)pyrido-benzoxazines, spiro(benzindoline)naphthoxazines, spiro(indoline)benzoxazines, fulgides and fulgimides.
 33. A photochromic compound according to claim 28 wherein R is an oligomer selected from the group consisting of polydialkylsiloxane oligomers.
 34. (canceled)
 35. A photochromic compound according to claim 28 wherein R is an oligomer selected from the group consisting of polyether oligomers, poly(C₁ to C₄ fluoroalkylene) oligomers and poly(di-(C₁ to C₁₀ hydrocarbyl)siloxane)oligomers.
 36. A photochromic compound according to claim 28 wherein R comprises a group of formula I(a) —(X)p(R1)q-R²  I(a) wherein: X is selected from oxygen, sulfur, amino such as C₁ and C₆ alkyl amino, C₁ to C₄ alkylene (preferably methylene); p is 0 or 1; q is the number of the monomer units R¹ in said oligomer and is preferably at least 5; R1 comprises di-(C₁ to C₁₀ hydrocarbyl)siloxane; and R² is selected from hydrogen, C₁ to C₆ alkyl and C₁ to C₆ haloalkyl, hydroxy, optionally substituted amino, optionally substituted aryl carboxylic acid and derivatives thereof.
 37. A photochromic compound according to claim 28 wherein the oligomer R is selected from the groups of the following formulae v:

wherein Ø is alkyl or aryl and includes at least a portion of aryl groups Xp(CF₂CF₂O)x-(CF₂)nCF₃  (vii) wherein X, and R² and p are hereinbefore defined and x is at least
 7. 38. A photochromic compound according to claim 28 wherein the oligomer R is linked to the photochromic moiety (PC) by a linker group of any one of the formulae selected from IIa to IIk:

wherein n is from 1 to 3;

wherein in the formula IIa to IIk: X which may be the same or different is as hereinbefore defined; R⁴ is selected from the group consisting of hydroxy, alkoxy, amino and substituted amino such as alkyl amino; n is an integer from 1 to 3; w is an integer from 1 to 4; q is an integer from 0 to 15; p which when there is more than one may be the same or different is 0 or 1; and (R) shows the radial for attachment of oligomer R.
 39. A photochromic compound according to claim 28 wherein the photochromic moiety (PC) is selected from the group consisting of chromenes, spirooxazines, fulgides, fulgimides and azo dyes.
 40. A photochromic compound according to claim 28 wherein the photochromic moiety (PC) is selected from the group consisting of: (a) spiro-oxazines of formula III

in the general formula III, R3, R4 and R5 may be the same or different and are each an alkyl group, a cycloalkyl group, a cycloarylalkyl group, an alkoxy group, an alklyleneoxyalkyl group, an alkoxycarbonyl group, a cyano, an alkoxycarbonylalkyl group, an aryl group, an arylalkyl group, an aryloxy group, an alkylenethioalkyl group, an acyl group, an acyloxy group or an amino group, R4 and R5 may together form a ring, and R³, R⁴ and R⁵ may optionally each have a substituent(s); (b) chromenes of formula XX

wherein B and B′ are optionally substituted phenylaryl and heteroaryl; and R²², R²³ and R²⁴ are independently selected from hydrogen; halogen; C₁ to C₃ alkyl; the group L(R)_(n); and the group of formula COW wherein W is OR25, NR²⁶R²⁷, piperidino or morpholino wherein R²⁵ is selected from the group consisting of C₁ to C₆ alkyl, phenyl, (C₁ to C₆ alkyl)phenyl, C₁ to C₆ alkoxyphenyl, phenyl C₁ to C₆ alkyl (C₁ to C₆ alkoxy)phenyl, C₁ to C6 alkoxy C₂ to C₄ alkyl and the group L(R)_(n); R₂₆ and R₂₇ are each selected from the group consisting of C₁ to C₆ alkyl, C₅ to C₇ cycloalkyl, phenyl, phenyl substituted with one or two groups selected from C₁ to C₆ alkyl and C₁ to C₆ alkoxy and the group L(R)_(n); R²² and R²³ may optionally from a carboxylic ring of 5 or 6 ring members optionally fused with an optionally substituted benzene and wherein at least one of the substituents selected from the group of substituents consisting of B and B′, R²², R²³, R²⁴, R²⁵, R²⁶ and R²⁷ is the group L(R)_(n); (c) fulgides and fulgimides of formula XXX:

wherein Q is selected from the group consisting of optionally substituted aromatic, optionally substituted heteroaromatic (where said aromatic/heteroaromatic may be mono or polycyclic aromatic/heteroaromatic); R³⁰ is selected from the group consisting of a C₁ to C₄ alkyl, C₁ to C₄ alkoxy phenyl, phenoxy mono- and di(C1-C4) alkyl substituted phenyl or phen(C₁ to C₄) A′ is selected from the group consisting of oxygen or ═N—R³⁶, in which R³⁶ is C₁-C₄ alkyl or optionally substituted phenyl, R³⁴ and R³⁵ independently represents a C₁ to C₄ alkyl, phenyl or phen(C₁ to C₄) alkyl or one of and R³⁴, R³⁵ is hydrogen and the other is one of the aforementioned groups, or R³⁴R³⁵=represents an adamantylidine group; and wherein at least one of Q, R³⁰, R³⁴, R³⁵ and R³⁶ comprises the group L(R)_(n); and (d) azo dyes of formula XL

wherein: R⁴⁰ and R⁴¹ are independently selected from the group consisting of hydrogen; C₁ to C₆ alkyl; C₁ to C₆ alkoxy; —NR⁴²R⁴³ wherein R⁴² and R⁴³ are as defined for R²⁶ and R²⁷; aryl (such as phenyl)aryl substituted with one or more substituents selected from C₁ to C₆ alkyl and C₁ to C₆ alkoxy, substituted C₁ to C₆ alkyl wherein the substituent is selected from aryl and C₁ to C₆ alkoxy, substituted C₁ to C₆ alkoxy wherein the substituent is selected from C₁ to C₆ alkoxy aryl and aryloxy.
 41. A photochromic compound according to claim 26 in which the fade half life of the compound in the standard photochromic cast test is at least 20% different compared with the corresponding photochromic compound in absence of the oligomer.
 42. A photochromic compound according to claim 40 wherein the fade half life is reduced by at least 40% compared with the corresponding photochromic compound without the oligomer.
 43. A photochromic compound according to claim 26 wherein said compound is formed by reaction of a photochromic moiety, optionally comprising a linker group, with a preformed oligomer.
 44. A photochromic compound according to claim 26 wherein said compound is formed by growth of on oligomer chain by living polymerization initiated on the photochromic moiety.
 45. A photochromic article comprising a photochromic compound of claim
 27. 46. A photochromic article according to claim 45 selected from optical lenses, face shields, goggles, visors, camera lenses, windows, automotive windshields, aircraft and automotive transparencies, plastic films and sheets, textiles and coatings, and inks.
 47. A method of preparing a photochromic compound comprising reacting a photochromic moiety with an oligomer to provide a photochromic compound which is an addict comprising a photochromic moiety and at least one pendant oligomer. 